Start Up Senior Trial Manager, Early Development

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn

more at  guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: R&D Operations Job Sub Function:
Clinical Trial Project Management Job Category:

Professional All Job Posting Locations:

High Wycombe, Buckinghamshire, United Kingdom

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at  are searching for the best talent for an expert Start-Up Senior Trial Manager, Early Development (ED) to support ED clinical trials in the UK, with hybrid responsibilities split across trial management and Study Start-Up Unit (SSU) activities.

As the business grows the expectation is the position shifts further towards the SSU within the ED environment. This is a hybrid, office-based role located High Wycombe, Buckinghamshire, UK with a planned move to Maidenhead in October 2026, requiring three days on-site each week.

Purpose:

The role serves as the primary country-level contact for assigned studies, delivering high-quality trial data, documentation and records in line with clinical protocols, ICH/GCP, Healthcare Compliance requirements, SOPs, and UK regulatory and ethical standards.

The successful candidate combines strong trial management experience with UK study start-up expertise, supporting studies from feasibility and start-up through trial conduct, database lock and close-out, as applicable. Working closely with study teams, sites, vendors and collaborators, you'll help ensure studies are delivered efficiently, compliantly and on time.

The role provides country-level oversight of assigned ED&CP studies, including local trial team coordination, site oversight, monitoring report review, issue and CAPA management, recruitment and data quality follow-up, and use of study systems and performance metrics to track progress.

The role also supports UK study start-up activities, including regulatory and ethics submissions, document readiness, approval tracking, partner coordination and management of start-up risks.

Acting as a link between ED operational delivery and SSU start-up activities, the successful candidate will help drive quality, consistency and efficiency through process improvement, training, mentoring and implementation of harmonised ways of working.

Are you ready to join our team? Then please read further!

You will be responsible for:

Early Development / Local Trial Management:

Acting as the primary local GCO contact for assigned ED&CP studies, leading local trial team activities in line with SOPs, procedures and regulations.

Overseeing studies from start-up through conduct and close-out, supporting delivery of recruitment, quality, timelines and budgets.

Supporting feasibility assessments, site selection and study planning, including risk and contingency management.

Tracking study and country progress using trial systems and reports, identifying risks and issues, implement corrective actions and keep study teams informed.

Reviewing monitoring reports, identifying trends across sites and supporting risk-based monitoring activities.

Ensuring local oversight of safety and quality processes, including safety reporting, CAPAs, informed…