Senior Scientist — Liposomal Formulation & Process Development

The Senior Scientist leads the design, development, and scale-up of liposomal, nanostructured lipid carrier (NLC), and encapsulated active systems across Flychem's portfolio, including liposomal retinaldehyde/retinol, THD ascorbate, copper tripeptide, recombinant collagen, and multi-molecular-weight hyaluronic complexes. The role owns the path from lab formulation through pilot and production-scale process, delivering robust, stable, and reproducible carrier systems for labile and difficult-to-deliver actives.

It combines hands-on formulation science with process engineering and technology transfer to manufacturing.

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Key Responsibilities

- Design and optimise liposomal, NLC, and encapsulated formulations for sensitive actives — retinol, retinaldehyde, tetrahexyldecyl ascorbate, bakuchiol, copper tripeptide, ceramides, azelaic and salicylic acid, arbutin, and enzyme actives — with a focus on stability, encapsulation efficiency, and payload protection.
- Develop and optimise carrier-manufacturing processes: thin-film hydration, ethanol/solvent injection, high-pressure homogenisation, microfluidisation, and extrusion; define and control critical process parameters.
- Select and justify lipid and carrier systems (lecithin, lysolecithin, phospholipids, glucosyl ceramide) and characterise the resulting dispersions.
- Characterise particle size, polydispersity index, and zeta potential by dynamic light scattering; determine encapsulation efficiency and drug loading via ultrafiltration/centrifugation coupled with HPLC/UPLC assay; assess morphology (TEM/cryo-TEM) where required.
- Lead scale-up from bench to pilot to production, ensuring reproducibility and yield; author process development reports, batch manufacturing records, and technology-transfer documentation.
- Design and interpret physical and chemical stability studies (including for oxidation- and light-sensitive actives) and define storage and packaging requirements.
- Partner with QC on analytical method suitability for encapsulated systems, and with Production/EHS on safe handling of solvents and hazardous inputs during scale-up.
- Provide technical guidance to junior scientists and contribute to project planning and troubleshooting.

Required Qualifications

- M.Sc / M.Pharm / M.Tech in Pharmaceutics, Chemistry, Chemical Engineering, Biotechnology, or a related discipline (Ph.D. in a relevant area is an advantage).
- 4–7 years of experience in formulation and process development, with demonstrable work on liposomes, NLCs/SLNs, or other encapsulation/delivery systems.

Required Technical Skills

- Liposome / lipid-carrier formulation and the associated unit operations (homogenisation, microfluidisation, thin-film hydration, extrusion).
- Colloidal characterisation: DLS (size/PDI), zeta potential, and encapsulation-efficiency determination.
- Working knowledge of HPLC/UPLC for assay of encapsulated actives, ideally in coordination with an analytical team.
- Formulation of labile actives and design of protective/encapsulated systems.
- Scale-up and technology transfer, with sound GMP documentation practice and awareness of cosmetic manufacturing requirements under the Cosmetics Rules, 2020.

Preferred / Nice-to-Have

- Experience in a cosmetic-ingredient, pharmaceutical, or nutraceutical manufacturing environment.
- Familiarity with peptide and protein actives (recombinant collagen, copper tripeptide) or fermentation-derived actives.
- Exposure to Design of Experiments (DoE) / QbD approaches to process optimisation.
- Understanding of regulatory and safety considerations for nano/encapsulated cosmetic ingredients.

Soft Skills & Behavioural Competencies

- Strong problem-solving and a structured, data-driven approach to development.
- Clear technical writing and communication across R&D, QC, and Production.
- Ability to manage multiple development projects and timelines.
- Mentoring instinct and collaborative working style.
- Ownership and rigour in translating lab work into reproducible manufacturing.

How to apply?

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