Advisor/Senior Advisor Linker-Payload, Antibody-Drug Conjugate and Bioconjugation Engineering
Listed on 2026-01-06
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Engineering
Research Scientist, Biotechnology
Advisor/Senior Advisor Linker-Payload, Antibody-Drug Conjugate and Bioconjugation Engineering
Join Lilly in Indianapolis to apply for the Advisor/Senior Advisor Linker-Payload, Antibody-Drug Conjugate and Bioconjugation Engineering role. Lilly is a global healthcare leader focused on life‑changing medicines.
Organization OverviewThe opportunity is within the Bioproduct Research and Development (BR&D) organization, a multidisciplinary team dedicated to the development and commercialization of small and large molecules, including monoclonal antibodies, novel therapeutics, and genetic medicines. The role focuses on linker‑payload chemistry and engineering for ADCs and AOCs.
Position SummaryWe seek highly motivated, technically creative professionals with experience in the small molecule–biologics interface. Desired experience includes linker‑payload (L‑P), ADC or AOC development, and conjugation chemistry. Candidates with strengths in pharmaceutical development, physical chemistry, crystallization, engineering, kinetic modeling, spectroscopy/PAT, bioconjugation, and purification are encouraged.
The Advisor / Senior Advisor will collaborate with cross‑functional teams to develop small molecule chemistry and unit operations for L‑P synthesis, ADC / AOC bioconjugation, and technical transfer to clinical and commercial manufacturing. They will also contribute to platform technologies such as continuous processing, automation, data mining, and process modeling.
Responsibilities and Opportunities- Drive and manage L‑P and bioconjugation development in‑house and at third‑party partners.
- Partner with process development and analytical science teams to deliver quality‑by‑design solutions.
- Contribute to future engineering strategy for clinical‑stage L‑P and bioconjugation.
- Develop work plans, experimental procedures, data requirements, and summaries.
- Author technical reports and CMC documents, including regulatory submissions (IND, IMPD, BLA).
- Publish research, attend conferences, and share knowledge on emerging technologies.
- Design and execute laboratory experiments for L‑P and ADC process design using manual and automated reactors.
- Apply engineering fundamentals to process design: heat and mass transfer, thermodynamics, crystallization kinetics, separations, drying, lyophilization, experimental design, and mixing theory.
- PhD in Chemical Engineering, Physical Chemistry, Chemistry, Biochemistry, or related field.
- 0–5 years of industry or graduate research experience developing drug substance manufacturing processes.
- Ability to work proactively, independently, collaboratively, and tenaciously in an interdisciplinary, fast‑paced environment.
- Experience with antibody‑drug conjugate modalities and novel conjugation chemistries.
- Experience with design of experiments, data collection, modeling, and scale‑up of manufacturing processes.
- Advanced computer skills: computational modeling, coding, data analysis, multivariate data analysis, machine learning, statistical DoE.
- Experience with hardware/software automation of processes and data workflows.
- Experience with online and offline analytical techniques and PAT (HPLC, GC, NMR, IR, Raman, XRPD, DSC, TGA, particle sizing, microscopy).
Actual compensation depends on education, experience, skills, and location. Anticipated wage: $129,000 – $209,000
. Full‑time employees are eligible for bonuses, a 401(k) program, pension, vacation, medical, dental, vision and prescription drug benefits, flexible spending accounts, life insurance, and well‑being benefits.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Lilly is dedicated to helping individuals with disabilities engage in the workforce.
Employee Resource GroupsERGs provide support networks; inclusive of groups such as Africa, Middle East, Central Asia Network;
Black Employees at Lilly;
Chinese Culture Network; JILN;
Lilly India Network; OLA; PRIDE; VLN; WILL; enAble. Learn more about all groups.
Seniority level:
Mid‑Senior level.
Employment type:
Full‑time. Industries:
Life sciences and pharmaceutical research.
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