Advisor – Engineering – Drug Substance

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. SMDD is seeking outstanding engineering candidates to work within the process design and development team. The position presents an opportunity to work side by side with chemists, analytical chemists, formulation scientists and other engineers to develop new technical solutions to accelerate our exciting portfolio.

Candidates must demonstrate a history of strong technical depth, scientific leadership, and a willingness to promote a collaborative, team-based approach to problem solving.

• Apply engineering fundamentals to design and optimize chemical processes for small molecules, oligonucleotides, and synthetic peptides, ensuring robust, scalable processes that reliably supply clinical trial materials.
• Design and execute lab experiments using knowledge of reaction kinetics, heat/mass transfer, thermodynamics, fluid dynamics, and process modeling to support error-free scale-up.
• Develop proficiency across a broad range of unit operations - including crystallization, filtration, drying, milling, and batch/continuous chemistry - to assemble complete synthetic manufacturing processes.
• Serve on integrated commercialization teams to collaboratively develop, test, and oversee process execution from lab scale through manufacturing facilities.
• Operate with full compliance within a regulated industry, adhering to applicable regulations, guidelines, SOPs, and safety procedures governing drug research and development.
• Collaborate cross-functionally with analytical, formulation, quality, regulatory, and environmental/safety teams to ensure comprehensive process development and compliance.
• Oversee scale-up and technology transfer to internal and external manufacturing sites through team meetings, site visits, and ongoing process monitoring.
• Maintain a continuous learning mindset by engaging with relevant literature, professional organizations, and the broader scientific community through publications and conference presentations.
• With experience, provide mentorship to junior scientists and engineers while driving documentation and broad sharing of new technologies, methodologies, and process control strategies.
• Foster an inclusive, collaborative environment that encourages diverse perspectives to deliver innovative solutions to unmet technical challenges.

• PhD in Chemical Engineering
• MSc in Chemical Engineering +7 years of experience in chemical/pharmaceutical process development
• BSc in Chemical Engineering +10 years of experience in chemical/pharmaceutical process development

• Experience with design, development, and optimization of synthetic process manufacturing unit operations.
• Experience with modeling and simulation tools, data analytics and predictive analytics.
• Experience in batch and continuous unit operations. Experience on technical considerations for equipment design and integration, process monitoring, integration of process analytical technologies (PAT) systems.
• Excellent oral communication and documentation skills.
• Demonstrate ability to effectively collaborate with multidisciplinary teams.
• Demonstrate leadership behaviors with ability to accept challenges, seek opportunities to remove barriers, influence without authority, and lead in areas of uncertainty
• Demonstrate exemplary teamwork/interpersonal skills
• Demonstrate problem solving, attention to detail and result oriented behaviors in a fast-paced environment.

• Travel: 0 to 10%
• Position Local:
  Indianapolis, IN LTC- N

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