Senior Process Engineer

Location – Mount Vernon, Indiana, U.S.

AstraZeneca is a global, innovation-driven biopharmaceutical company. We focus on the discovery, development and delivery of life-changing medicines for patients, while working to minimize the environmental impact of our activities. We are proud of a culture that inspires innovation and collaboration, empowers colleagues to express diverse perspectives, and ensures that people feel valued and respected for their ideas and creativity.

At AstraZeneca, we are united by a common purpose: to push the boundaries of science to deliver life-changing medicines. Every single day, we make a difference by delivering potentially life-changing medicines to millions of people globally and by leading breakthrough science that promises to transform the treatment of disease. Our purpose is ambitious and so is our approach. Becoming a more agile and creative company means building a dynamic, inspiring culture where we celebrate diverse, bold thinking and act with a sense of urgency.

We are curious, creative, and open to new ideas and ways of working.

We work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity, including in difficult situations, because we are committed to doing the right thing. We believe in the potential of our people and actively support colleagues to develop and achieve more than they thought possible.

Technical Operations Science & Innovation (TOSI) provides scientific and engineering expertise to support the manufacture, continuous improvement, and lifecycle management of AstraZeneca products, working across internal manufacturing sites, external suppliers, and cross‑functional product teams to strengthen process understanding, resolve technical challenges, and ensure reliable product supply. This global role is based at AstraZeneca's strategic U.S. Oral Solid Dose manufacturing site, which also serves as a key hub for the introduction of new manufacturing technologies.

This role offers the opportunity to apply and broaden your experience in the technical support of commercial pharmaceutical products and manufacturing processes. You will work on real-world technical challenges that directly affect product supply, process robustness and lifecycle management.

• Apply and extend your capability in mechanistic and physics‑informed process modelling through relevant product and project work.
• Collaborate with experienced engineers and specialists in process engineering, materials science, PAT, data science, equipment engineering and pharmaceutical development.
• Translate physical understanding into mathematical descriptions, identify the data needed to test model assumptions, and apply models to support technical decisions.
• Gain exposure to a broad range of products, manufacturing technologies and sites while working with internal teams and external partners.
• Take ownership of increasingly complex work packages and broaden your technical leadership responsibilities.

• Provide process engineering support to a prioritized portfolio of commercial products manufactured at AstraZeneca sites and by external partners.
• Plan and deliver defined technical work packages, working with manufacturing sites and cross‑functional specialists.
• Apply engineering fundamentals and structured problem‑solving to understand manufacturing processes and resolve process or equipment‑related issues.
• Develop and test mechanistic explanations of process behavior using calculations, experimental evidence and manufacturing data.
• Develop and apply quantitative process descriptions, including mass and energy…