Sr. Principal Infrastructure Architect – Manufacturing & Quality Systems
Listed on 2025-12-27
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IT/Tech
Systems Engineer, Cybersecurity, Cloud Computing
Sr. Principal Infrastructure Architect – Manufacturing & Quality Systems
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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life‑changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first.
We’re looking for people who are determined to make life better for people around the world.
As we continue enabling advanced manufacturing capabilities, we are seeking a Sr. Principal Infrastructure Architect to provide strategic technology leadership across Indianapolis Parenteral Manufacturing (IPM), Indianapolis Device Assembly & Packaging (IDAP), and Indianapolis Device Manufacturing (IDM).
What You'll Be DoingThe Sr. Principal Infrastructure Architect will design and govern IT infrastructure supporting GMP‑regulated manufacturing execution, laboratory, and quality systems. You will ensure resilient, secure, and compliant platforms that enable operational reliability and digital transformation.
Key Responsibilities- Develop and maintain infrastructure architecture roadmaps for IPM, IDAP, and IDM, aligned with Tech@Lilly strategy.
- Lead infrastructure readiness for the transition from PMX to Pharma Suite and other key MES modernization initiatives.
- Architect secure, validated networking, compute, storage, and virtualization platforms supporting MES, EWM/WMS, Quality Systems, and S95 Level 2+ solutions.
- Provide technical leadership and escalation support for complex operational and cybersecurity challenges.
- Ensure compliance with GMP, GxP, CSV, and data integrity standards.
- Lead major infrastructure deployments and modernization programs across all three manufacturing areas.
- Partner with operations, engineering, automation, cybersecurity, and global architecture teams to deliver scalable solutions.
- Excellent communication and executive influence skills.
- Strong analytical capabilities with a proven track record of solving complex operational technology challenges.
- Experience working in fast‑paced, operationally critical environments with multiple stakeholders and competing priorities.
- Bachelor's degree in Computer Science, Engineering, Information Systems, or related field.
- 5+ years of experience architecting IT infrastructure in GMP‑regulated pharmaceutical or advanced manufacturing environments.
- 2+ years of working with MES, EWM/WMS, DCS, Industrial IoT networks, and S95 Level 2+ architectures.
- Demonstrated ability to lead multi‑site infrastructure programs and influence executive technology decisions.
- Expertise in secure architecture design, disaster recovery, and operational resiliency.
- Experience supporting parenteral and/or device manufacturing.
- Familiarity with Pharma Suite, PMX, SAP EWM, or other MES/WMS platforms.
- Certifications or networking/security credentials preferred.
- Experience with hybrid cloud models, edge technology, and modern cybersecurity controls.
- Strong interpersonal skills and ability to build capability within teams through coaching and thought leadership.
This role offers the opportunity to shape the digital foundation that enables Lilly to reliably deliver life‑changing medicines for patients around the world.
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender…
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