Principal Quantitative Scientist

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come.

Join Roche, where every voice matters.

Roche Diagnostics has built a new strategic area – Roche Information Solutions (RIS) - charged with creating a modern portfolio of decision support software products and generating insights that change the way patients are cared for. Our challenge is to bring together complex diagnostic and treatment data from medical devices and IT systems and intelligently process and present this data to clinicians, researchers, and caregivers to improve research outcomes and patient care by offering a suite of Clinical Decision Support (CDS) solutions.

This role requires 3 days of being on-site in Indianapolis.

As a Senior Principal Quantitative Scientist, you will act as a leading scientific authority for Real-World Data (RWD), driving evidence generation that fundamentally shapes the development and adoption of our digital health, and IVD portfolio. This is a high-impact, independent, and externally facing role requiring scientific leadership, deep expertise, and the ability to influence critical business, regulatory, and long‑term strategic decisions.

Your work will involve leveraging diverse data types, including EHR, claims, omics, and digital health data.

RWD Strategy & Execution (End‑to‑End Leadership) Drive the conceptualization, planning, execution, and reporting of complex, advanced RWD studies using various research and commercial healthcare databases. Develop RWD study protocols and independently lead complex analyses to support the evidence needs of the IVD and digital health portfolio, across multiple therapeutic areas. Ensure the design, execution, and presentation of RWE adhere to the highest scientific and methodological standards.

Strategic Influence & Adoption (Thought Leadership) Act as the go‑to RWD leader, working closely with cross‑functional stakeholders such as Product Leads and Medical Affairs to ensure RWD projects directly support commercial, market access, and regulatory needs. Champion RWD's use to supplement clinical evidence and actively identify and drive implementation of opportunities where RWD can serve as the primary evidence mechanism to achieve regulatory and reimbursement objectives.

Represent Roche as a recognized subject‑matter expert with external partners (KOLs, academic institutions, healthcare authorities), leading joint publications on study design and fostering strong relationships to explore new data assets and analytical methodologies. Expertise & Mentorship Serve as the internal authority on RWD sources, epidemiology, and state‑of‑the‑art methodologies, setting best practices for the entire RWD function. Proactively drive innovation by defining and implementing enhanced ways of working (processes, methods, technology) and proactively sharing learnings with peers.

Routinely mentor junior colleagues and act as an influential subject‑matter expert across the organization.

You hold a PhD (preferred) OR Master’s Degree in a Quantitative Science field (e.g. Pharmacoepidemiology, Epidemiology, RWD Biostatistics, Pharmacoeconomics, Health Economic and Outcomes Research, or related). 7+ years of directly related (industry, consulting, or other relevant) experience, demonstrating increasing levels of responsibility and…