Clinical Data Scientist

Location: Indianapolis, IN Metro (Hybrid / 3-Day Onsite) (Open to Regional/EST Candidates with Onsite Travel)

Contract Type: Contractor Full-Time / Enterprise Project Engagement (Outsourced via Xenon7)

Where elite tech talent meets world-class opportunities! At Xenon7, we work with leading enterprise clients and innovative startups on high-impact projects across Data, AI, Cloud, and Software Engineering. Our expertise in AI solution architecture and specialized technical talent allows us to partner with enterprise leaders on transformative initiatives, driving innovation and business growth.

Lead the development and application of digital twins to improve clinical trial design and support evidence-based clinical development decisions. The role prioritizes digital-twin, simulation, and AI/ML expertise, supported by clinical-development experience and close partnership with trial-design experts.

You will join a multidisciplinary clinical development environment and partner with clinical scientists, physicians, biostatisticians, pharmacometricians, biomarker experts, data scientists, data engineers, and other stakeholders. You will translate clinical development questions into quantitative strategies and deliver interpretable analyses that inform protocol design, patient selection, endpoint strategy, dosing, operational planning, and decision‑making under uncertainty.

The role prioritizes digital twins as the primary capability for simulating patients, disease trajectories, treatment response, and clinical trials. The successful candidate will bring strong digital‑twin, simulation, and AI/ML expertise, along with sufficient clinical‑development knowledge to work effectively with trial teams. Deeper trial‑design expertise can be developed through close collaboration with clinical scientists, biostatisticians, and pharmacometricians.

• Lead the design, development, and evaluation of digital twins of patients, disease trajectories, treatment response, or clinical trials using clinical trial and relevant external data.
• Combine mechanistic, statistical, causal, and machine learning approaches to create fit‑for‑purpose digital twins that can be simulated under alternative populations, interventions, dosing strategies, endpoints, or trial designs.
• Define use cases and contexts of use with clinical and quantitative experts so each digital twin addresses a specific trial‑design or development decision.
• Assess calibration, validation, robustness, transportability, uncertainty, and practical relevance using appropriate internal and external evaluation strategies.
• Develop reproducible workflows and reusable digital‑twin components that can be applied across programs or therapeutic areas.

• Partner with trial teams to frame development questions and evaluate design options, including target populations, eligibility criteria, enrichment strategies, comparators, endpoints, visit schedules, dosing strategies, and operational tradeoffs.
• Use digital twins and complementary simulation methods to compare plausible scenarios, characterize uncertainty, and support model‑informed decision‑making.
• Work closely with statisticians and pharmacometricians so analyses complement established trial‑design methods and align with clinical and regulatory objectives.
• Communicate assumptions, limitations, and decision‑relevant insights clearly to technical and non‑technical stakeholders.

• Analyze and integrate clinical trial data and, where relevant, biomarkers, imaging, digital health data, omics, patient‑reported outcomes, and…