Post Doctoral Appointee

Position Title

Post Doctoral Appointee – Indiana University

The Tadepalli Lab investigates how myeloid cells regulate immune outcomes during cancer therapy. Our research focuses on defining the molecular and functional heterogeneity of myeloid populations in response to radiotherapy and immunotherapy, and on leveraging this knowledge to engineer precision nanotherapeutics that reprogram their behavior. By integrating molecular engineering with cancer immunology, we design nano‑enabled therapeutics that modulate immune signaling and enhance crosstalk between myeloid and lymphoid cells.

Our interdisciplinary research program spans immunology, nanotechnology, materials science, and molecular engineering, bringing together tools such as flow cytometry, animal models, and bio/nanomaterial synthesis. Our long‑term goal is to establish mechanistic and translational understanding of radiation‑induced immune responses and design nanotherapeutics for precision medicine.

We are seeking a highly motivated post‑doctoral fellow to lead mechanistic and translational studies focused on how engineered nanomaterials can modulate myeloid cell function to improve radiotherapy and immunotherapy outcomes. The position involves:

• Designing and executing in vivo tumor and radiation experiments in murine models
• Performing high‑dimensional immunophenotyping, transcriptomics, mouse colony management, and molecular biology assays
• Collaborating on nanomaterial synthesis and functionalization for targeted immune modulation
• Performing mechanistic assays to define immune activation and signaling pathways
• Preparing figures, manuscripts, and contributing to grant development

• PhD in Immunology, Cancer Biology, Biomedical Engineering, or a related discipline
• Demonstrated experience in mouse handling and tumor models
• Experience in nanomedicine/biomedical engineering
• Strong experimental design skills and a record of research productivity
• Excellent written and verbal communication abilities

• Background in cancer immunology or radiation immunotherapy
• Experience with multicolor flow cytometry and data analysis
• Familiarity with nanoparticle synthesis and characterization for biomedical applications
• Interest in multidisciplinary collaborations and mentoring

Priority Application Review Deadline: 01/01/2026
Expected

Start Date:

02/01/2026
Posting Number: IUSM-

Gerri Herron
HR Coordinator
geherron