Advisor - Biophysical​/Analytical Scientist, Molecular Insights

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve.

This is hard, urgent, selfless work-but it's work worth doing. If you're driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

** Overview*
* At Lilly, we unite caring with discovery to make life better for people around the world. Eli Lilly and Company's Biotechnology Discovery Research (BioTDR) organization is responsible for discovering and optimizing novel biotherapeutic medicines (proteins, peptides, antibodies, fusions, viral and non-viral genetic medicines, and bioconjugates) for advancement into clinical research in key areas of unmet medical need including diabetes, obesity and related complications, oncology, immunology, neuroscience, and more.

An essential component for success is ensuring the generation of drug candidates with biopharmaceutical properties that enable successful manufacturing, formulation, and drug delivery.

The Lead Optimization group within BioTDR is seeking a talented, curious, and driven candidate to join our diverse, interdisciplinary Molecular Insights team as a Biophysical/Analytical Scientist. This role requires deep expertise in biophysical and analytical characterization of biotherapeutics, with the flexibility to apply that expertise across complex and emerging modalities as project needs evolve. The ideal candidate combines strong technical depth with the collaborative skills to partner effectively with both Research and Development stakeholders.

** Responsibilities*
* + Serve as the primary biophysical/analytical point-of-contact for assigned programs, independently driving strategic decisions and partnering directly with project and platform teams on develop ability, characterization, and formulation-related questions

+ Collaborate with protein engineers, medicinal chemists, preclinical biologists, ADME scientists, and other stakeholders to use characterization data to inform SAR and risk assessment

+ Apply deep biophysical and analytical expertise flexibly across diverse and complex modalities as project and platform needs evolve

+ Execute and interpret orthogonal biophysical and analytical characterization across chromatographic (RP-HPLC, aSEC, HILIC, IEX), electrophoretic (CE-SDS, cIEF), spectroscopic (nanoDSF, CD, SoloVPE), light scattering (SLS, SEC-MALS, DLS, CG-MALS), calorimetric (ITC, DSC), and binding/kinetic (SPR, Octet) methods to support develop ability and candidate selection decisions

+ Apply computational or structure-based modeling methods (e.g., Schrödinger, MOE, molecular dynamics), where applicable, to complement biophysical data and inform candidate selection decisions

+ Apply statistical analysis using software such as JMP or Prism to evaluate experimental data and support data-driven decisions

+ Search and review relevant scientific literature and the external environment more broadly to identify innovation opportunities and best practices applicable to biophysical and analytical characterization

+ Accurately document experimental procedures and communicate results via presentations, written reports, and electronic notebooks following established procedures

** Basic Qualifications*
* + Ph.D. in biochemistry, biotechnology, analytical chemistry, chemical engineering, pharmaceutical sciences, or a related field with at least 2 years of relevant industry experience, or M.S. with at least 7 years of relevant industry experience.

** Additional Skills/Preferences*
* + Demonstrated deep expertise in biophysical characterization methods (e.g., light scattering, spectroscopic, chromatographic, calorimetric, and binding kinetics) to enable drug candidate selection and development, along with strong analytical capabilities applied to biotherapeutic candidates.

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Experience with complex modalities, such as antibody-drug conjugates, bispecific mAbs, antibody-peptide conjugates, or other bioconjugates

+ Hands-on experience with Biacore/SPR, Octet/BLI, or other binding kinetics platforms

+ Familiarity with laboratory automation and high-throughput characterization platforms

+…