Advisor ADC Drug-Linker Synthetic Process Development

The current position focuses on small-molecule drug-linker synthetic chemistry.  The current opportunity is within the Bioproduct Research and Development (BR&D) organization, which is a multidisciplinary organization focused on the development and commercialization of biologic therapeutics such as monoclonal antibodies and bioconjugates.  Due to a strategic commitment to the growth of novel modalities such as Antibody-Drug Conjugates (ADCs) and an exciting pipeline of investigational medicines within the Lilly portfolio, we are seeking outstanding candidates to work at this exciting small molecule – biologics interface.  

The successful candidate will interface closely with the biologics development in  &D and with the Synthetic Molecule Design and Development organization (SMDD) at Lilly.
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* Position Responsibilities:

** To meet the needs of Lilly’s expanding and diverse portfolio of ADCs, our team is tasked with growing the chemistry infrastructure to conduct the synthesis and process development of highly-potent and/or cytotoxic ADC drug-linkers. We will utilize a combination of in-house and external development, while building the capabilities to develop and transfer processes to internal and external manufacturing partners. A successful applicant should bring a skillset and knowledge to help grow our team’s capabilities, research facilities, and infrastructure.  

Lilly has an expanding and diverse portfolio of ADCs that require thorough drug-linker process development. Possess fluent knowledge in synthetic organic chemistry methods, technologies, and techniques and apply these skills to design and develop robust synthetic manufacturing processes for use in clinical manufacturing campaigns. Support generating data to be used in regulatory filings. Possess ability to address key CMC regulatory questions that enable clinical studies.

** Basic Requirements:
** experience OR MS degree with 5+ years of relevant synthetic chemistry experience in an industry setting.
** Additional Skills/Preferences:
** Experience working in a high-potent laboratory environment, with experience handling and manipulating high-potent and/or cytotoxic compounds is a plus.

Experience working with Antibody-Drug Conjugates (ADCs) is a plus.

Familiarity with preparative scale chromatographic purification of small molecules.  At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world.
We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!
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