Research Scientist , Biochemistry and Microbiology Division

New England Biolabs® is a different kind of biotechnology company – we are a community of scientists, innovators and collaborators driven by a shared mission to advance science for the benefit of society. Founded in 1974 with a deep commitment to research excellence and environmental stewardship, NEB® has become a global leader in the discovery and production of enzymes for molecular biology applications.

Our reagents are trusted by researchers worldwide for their quality and reliability and have played a critical role in breakthroughs across genomics, proteomics, diagnostics and academic research. With a corporate culture rooted in passion, humility and authenticity, we offer a dynamic and inclusive workplace where creativity thrives, voices are heard, and personal growth is celebrated. Whether you are interested in pursuing a research career or supporting our mission through other roles, joining NEB means contributing to meaningful scientific progress in a collaborative, campus-like environment that values both innovation and integrity.

We are inviting applicants for the position of Research Scientist I. Reporting to the Associate Director of Research (Biochemistry and Microbiology Division) and working in close collaboration with the Research Cores, you will be an integral member of the Design-Build-Test-Learn (DBTL) Team responsible for our protein engineering efforts. You will be the team’s link between enzyme biochemistry at the bench and automated, high-throughput engineering.

• Design:
  Apply your knowledge of enzyme chemistry and structure to guide residue selection and engineering strategy.
• Assay translation:
  Work with research labs to translate assays for a variety of enzyme families into robust, high-throughput formats, optimizing them for throughput and automation before handing them to the Functional Screening Core for testing.
• Kinetic workflows:
  Establish high-throughput kinetic workflows and manage data generation and analysis using modern kinetic tools.
• Build:
  Advise on clone design and protein purification needs, and work with the Cloning and Protein Purification Core on defining the best strategies.
• Test:
  Validate successful hits from the Functional Screening Core and biochemically characterize the most promising ones using high-throughput kinetics.
• Learn:
  Interpret results together with the Bioinformatics Core and advise on the design of the next engineering cycle.

• Ph.D. in a scientific discipline with 1-2 years of academic or industry experience.
• Working knowledge of protein structure-function relationships and mechanistic enzymology.
• Experience with directed evolution or protein engineering.
• Experience developing or miniaturizing plate-based assays; familiarity with liquid-handling automation is required.
• Ability to collaborate effectively across labs and core facilities.
• Strong ability to multitask and perform effectively under pressure while maintaining high attention to detail.
• Excellent organizational and communication skills, including rigorous lab notebook practices.
• Proven “good hands” at the bench and the ability to perform careful and consistent experiments.

• Knowledge of electron pushing and organic chemistry.
• Experience across diverse enzyme families.
• Creativity and an innovative approach to problem-solving.
• Excitement for continued learning and for tackling new projects.

Estimated base salary hiring range for this position is $80,000-$90,000 Base salary is one component of our generous total rewards compensation package.

Employees are eligible to receive:

• Annual discretionary profit-sharing bonus
• Participation in our Employee Stock Ownership Plan "ESOP" (eligible after two full years of…