Associate Scientist

Associate Scientist / Histotechnician

Irvine, CA 92612

8+ months (possible extension- performance based)

We are seeking a detail-oriented and experienced histotechnician for an contract position supporting routine histology and immunohistochemistry (IHC) operations within the histology laboratory for Skincare R&D and Clinical Development.

This is a hands-on, lab-based role responsible for the processing, sectioning, and staining of formalin-fixed paraffin-embedded (FFPE) tissues, as well as performing special stains, IHC assays, and associated imaging/documentation.

The ideal candidate is comfortable working independently in a fast-paced environment, maintains rigorous attention to quality and consistency, and has solid foundational histology bench skills.

• Perform routine processing of FFPE tissue specimens, including trimming, embedding, and block preparation
• Section FFPE tissue blocks using a microtome to produce high-quality, consistent slides for downstream analysis
• Perform routine histology staining (e.g., H&E) and special stains (e.g., Fontana-Masson, Resorcin Fuchsin, Herovici, etc.) per established SOPs
• Perform manual and/or automated immunohistochemistry (IHC) staining, including antigen retrieval, antibody optimization support, and chromogenic/fluorescent detection
• Operate and maintain histology laboratory equipment (microtomes, tissue processors, embedding stations, autostainers, cover slippers)
• Perform slide imaging/scanning and organize digital image files for study team review
• Maintain accurate, detailed records of samples, staining runs, and quality control checks in line with lab documentation practices
• Troubleshoot staining and tissue quality issues, escalating as appropriate
• Ensure proper labeling, tracking, and chain-of-custody for tissue specimens and slides
• Maintain lab supplies, reagents, and equipment calibration/maintenance logs
• Adhere to all laboratory safety protocols, including handling of chemicals (formalin, xylene, etc.) and biohazardous materials
• Support general lab organization, inventory management, and cleanliness standards
• Collaborate with scientists and lab management within Skincare R&D and Clinical Development to meet study timelines and quality expectations

• Associate's or Bachelor's degree in a relevant scientific field (e.g., Biology, Medical Laboratory Science, Histotechnology)
• Minimum of 1-3 years of hands-on experience in a histology laboratory, including FFPE tissue processing, microtome sectioning, and routine/special staining
• Strong attention to detail and consistency in a high-throughput lab environment
• Ability to work independently with minimal supervision while following established SOPs
• Good documentation and record-keeping habits
• Ability to safely handle laboratory chemicals and biological specimens
• HT or HTL certification (ASCP) or eligibility
• Demonstrated experience performing IHC staining (manual and/or automated platforms)
• Familiarity with slide imaging/digital scanning workflows
• Experience with automated IHC/special stain platforms (e.g., Leica Bond, Ventana/Roche Discovery, Dako Autostainer)
• Experience with whole-slide imaging/scanning systems
• Prior experience in a pharmaceutical, biotech, or CRO research lab setting (as opposed to clinical diagnostics)
• Familiarity with GLP or GxP laboratory documentation practices
• Experience in skincare/dermatology-focused research or clinical development studies is a plus