IT Quality Compliance Manager - Hybrid

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At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives. We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting‑edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?”

That question drives everything we do. But our mission doesn’t stop with cancer. We’re pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose. Join us in our mission to improve the human condition across multiple diseases. If you’re passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

The IT Quality Compliance Manager will oversee the design, implementation, and ongoing management of IT controls to ensure compliance with internal and external requirements, primarily Sarbanes‑Oxley (“SOX”) and SOC 2. The role coordinates with cross‑functional teams across IT, Security, Finance, Accounting, Quality and Internal Audit to ensure controls are properly designed and documented. It also acts as a liaison between internal teams and external auditors.

Reporting to the Senior Director – Software Quality, the individual plays a key role in risk identification, control enhancements, and process improvements to support a sustainable compliance program aligned with industry standards and regulatory requirements.

• Oversee an integrated control framework designed to support our internal and external compliance requirements.
• Lead the design, implementation, and maintenance of IT General Controls (ITGCs) and application controls for SOX and SOC 2 compliance. Provide updates to IT process documentation, risk control matrices, and control narratives.
• Serve as the main point of contact for all ITGC‑related inquiries, walkthroughs, and testing. Manage the timely collection, review, and submission of audit requests.
• Establish compliance calendars and testing schedules associated with walkthroughs, testing, and remediation activities that align with external auditors and internal stakeholders.
• Monitor and advise on remediation efforts for identified deficiencies and ensure timely resolution.
• Support control activities related to coordination of quarterly user access reviews across multiple applications and implementation and monitoring of quarterly segregation of duty reviews for change management.
• Collaborate cross‑functionally to proactively identify control gaps and drive continuous improvement of the control environment.
• Develop policies, procedures, and standards to strengthen IT governance and regulatory compliance.
• Report on compliance status, risks, and remediation progress to management and stakeholders.
• Maintain up‑to‑date knowledge of industry advancements in IT audit and cybersecurity methodologies.

• Bachelor’s degree in Information Systems, Accounting, Finance or related field.
• 5+ years of IT audit experience within Public Accounting or Internal Audit.
• Professional certification (CISA, CIA, CISSP, CISM, CRISC).
• 5+ years of experience with SOX or SOC 2.
• 3+ years of experience leading audit engagements.
• Experience working with external auditors and managing compliance assessments.
• Excellent project management skills.
• Ability to communicate effectively with both technical and non‑technical audiences.

• Life science, biotechnology, healthcare, and/or laboratory industry experience a plus.
• Proven track record of growth in an auditing role within a company.
• Familiarity with systems like Jira, Git Lab, Service Now, and Okta.
• Strong influencing and negotiating skills.
• Highly self‑motivated, self‑directed, and attentive to detail.
• Ability to excel in a fast paced and rapidly changing environment.
• Ability to work independently with minimal supervision and seek guidance as needed to clarify…