Research Fellow-Neuroscience-Grinberg lab

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• Medical:
  
  Multiple plan options.
• Dental:
  
  Delta Dental or reimbursement account for flexible coverage.
• Vision:
  
  Affordable plan with national network.
• Pre-Tax Savings:
  
  HSA and FSAs for eligible expenses.
• Retirement:
  Competitive retirement package to secure your future.

A Postdoctoral Fellow position is available in the Neurodegeneration and Sleep Pathology Laboratory at Mayo Clinic under the leadership of Dr. Lea T. Grinberg.

The laboratory investigates the biological basis of sleep and circadian dysfunction in aging and neurodegenerative diseases using deeply characterized human brain tissue. Our group has generated single cell, spatial transcriptomic, and spatial proteomic datasets spanning normal aging, Alzheimer disease, progressive supra nuclear palsy, atypical Alzheimer disease variants, Lewy body disease, and related disorders, linked to detailed neuroanatomical, neuropathological, clinical, and sleep phenotyping.

The fellow will join a collaborative, multidisciplinary team integrating molecular data with anatomy, cell biology, neural circuits, and disease mechanisms. We are seeking a candidate who will think first about the biological question and use genomic and computational tools to answer it. The ideal candidate will have a strong neuroscience foundation, preferably in neurodegeneration, and sufficient experience with large-scale omics data to independently formulate and test hypotheses.

A candidate does not need to be a pipeline developer, software engineer, or dedicated bioinformatician.

• Develop and lead biologically driven projects focused on neural circuits, cell types, sleep and circadian dysfunction, and mechanisms of neurodegeneration.
• Analyze and interpret single cell, spatial transcriptomic, spatial proteomic, and related molecular datasets from human brain tissue.
• Integrate molecular findings with neuroanatomical, neuropathological, clinical, and sleep phenotypes, and use public datasets to validate or extend findings.
• Investigate selective neuronal vulnerability and resilience and develop models linking molecular changes to neuronal dysfunction, circuit disruption, and clinical phenotypes.

• Understand the strengths, limitations, and biological assumptions of common omics analytical approaches.
• Independently explore datasets, identify biologically meaningful patterns, and develop testable hypotheses.
• Select appropriate analytical strategies, critically evaluate results, and communicate effectively with quantitative collaborators.
• Translate complex molecular patterns into biological, anatomical, and disease-relevant interpretations. The emphasis is scientific discovery.

• Lead manuscripts, abstracts, presentations, and contributions to grant or fellowship applications.
• Present findings at internal seminars and scientific meetings and conferences.
• Collaborate across neuroscience, neuropathology, sleep medicine, computational biology, and related disciplines.
• Mentor trainees or junior team members as appropriate and contribute to multidisciplinary scientific discussions.

This position provides access to rare human brain datasets combining modern…