Senior Research Associate​/Associate Scientist- Antibody Biophysical Characterization

Full Time

The heart of Prellis Bio’s strategy is the combination of novel, cutting-edge methods in machine learning, biology at scale, and next-gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids, enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.

Our growing pipeline spans obesity, inflammation and immunology (I&I), and oncology. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

Position Summary

We are seeking a Senior Research Associate / Associate Scientist — Antibody Biophysical Characterization to join our High Throughput Discovery group
. You will characterize therapeutic antibody candidates using biophysical binding platforms (SPR and BLI) and support assay development for the screening and characterization pipeline, contributing to end-to-end antibody discovery campaigns. You will be responsible for:

• Antibody characterization on SPR platforms (Carterra, Biacore): binding kinetics, affinity determination, and epitope binning and mapping.
• BLI (Octet) supports for antibody discovery
  : antibody supernatant quantification, antigen QC for immunization campaigns, and affinity measurement.

This role sits within a highly cross-functional High Throughput Discovery group
, with significant opportunities to grow and take on new responsibilities. The ideal candidate will thrive in a dynamic, hands-on environment and play a critical role in delivering life-changing therapeutics.

Responsibilities

• Perform SPR-based antibody characterization (Carterra LSA/LSAXT or Biacore) to assess binding kinetics, affinity determination, and epitope binning and mapping across multiple antibody discovery projects.
• Perform BLI (Octet) assays for antibody supernatant quantification, reagents QC, and affinity measurement.
• Develop and optimize SPR and BLI assays — including method design, reference/positive controls, and reagent qualification — to support new antibody discovery projects.
• Support antigen protein QC and characterization for immunization campaigns — confirming binding activity, purity, and stability to ensure high-quality antigen preparations for animal immunization.
• Work with existing lab automation systems and liquid handlers (Biomek, Lynx, or similar) to support high-throughput screening.
• Independently troubleshoot and contribute to protocol optimization for enhanced efficiency and increased throughput.
• Collaborate with cross-functional teams including Discovery, Production, and Data Science / AI/ML, providing technical support for automated workflows and proactive communication.
• Maintain accurate ELN documentation and present experimental results clearly in team meetings.

Qualifications

• Senior Research Associate level: BS in Molecular Biology, Immunology, Biotechnology, or related life science field with 4+ years of relevant experience, or MS with 2+ years.
• Associate Scientist level: BS with 6+ years, or MS with 3+ years of direct relevant industry experience. Level can be adjusted based on experience.
• Hands-on experience with SPR-based antibody characterization (Carterra LSA/LSAXT, Biacore, or comparable), including binding kinetics, affinity determination, epitope binning and mapping, and assay development / optimization.
• Hands-on experience with BLI (Octet or comparable) for antibody supernatant quantification, antigen QC, and kinetics/affinity measurement.
• Background in ELISA-based antibody…