Associate Director​/Director​/Senior Director, Clinical Biomarkers

* Note:

exact level depending on experience*

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide foot printing of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.)

against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.

This role will champion and support bidirectional translational medicine strategy, ensuring that discoveries are effectively translated into clinical development while clinical findings are systematically reverse-translated to inform discovery research, preclinical models, biomarker strategies, and the design of future clinical studies.

The candidate will serve as the translational lead across multiple programs, partnering closely with Discovery Biology, Pharmacology, Toxicology, Clinical Development, Bioinformatics, Clinical Operations and Regulatory. The role requires a highly collaborative leader with deep expertise in translational science, biomarker strategy, human disease biology, and precision medicine.

• Develop and lead integrated translational medicine strategies across discovery, IND-enabling, and clinical-stage programs.
• Define translational plans that maximize the probability of technical, clinical, and regulatory success for first-in-class assets.
• Establish translational milestones supporting efficient progression from target validation through clinical proof-of-concept.
• Support reverse translational medicine efforts by integrating emerging clinical observations with preclinical research to continuously refine biological understanding and therapeutic hypotheses.
• Translate clinical efficacy, safety, biomarker, PK/PD, and patient heterogeneity data into mechanistic hypotheses that inform new preclinical experiments and platform capabilities.
• Partner with Discovery Research to design and prioritize follow-up studies that investigate mechanisms of response, resistance, toxicity, target biology, and disease progression observed in clinical studies.
• Drive an iterative bench-to-bedside-and-back approach that enables continuous learning across the portfolio and accelerates first-in-class drug development.
• Utilize clinical data to refine target product profiles, patient selection strategies, biomarker hypotheses, and future development plans.
• Collaborate with Clinical Development and Biostatistics to ensure translational learnings from ongoing and completed studies directly influence the design of subsequent clinical trials, including patient populations, endpoints, biomarker incorporation, dose optimization, and combination strategies.
• Lead multidisciplinary data review meetings to integrate clinical, biomarker, imaging, genomic, and pharmacology data into actionable development decisions.
• Establish a framework…