Principal Development Scientist

Principal Development Scientist.

We are seeking a highly motivated Principal Scientist to join our Deeside process development team. Our bioconjugation scientists play a critical role in bridging the gap between small-molecule chemistry and large-molecule biologics, primarily focusing on the development and scale-up of Antibody-Drug Conjugates (ADCs) and other bioconjugates. You will execute and manage the delivery of projects supporting our clients early‑stage research and then progress lead candidates into clinical‑scale manufacturing, ensuring high‑quality drug candidates are ready for the clinic.

• Process Design & Optimization:
  Independently design and execute experiments to develop scalable bioconjugation and purification processes.
• Scale‑up & Tech Transfer:
  Transition processes from bench‑top research to larger‑scale production while maintaining product quality.
• Downstream Processing:
  Optimize purification workflows using ÄKTA chromatography systems and Tangential Flow Filtration (TFF).
• Analytical Characterization:
  Perform in‑depth product analysis using HIC, SEC, IEX, and LC‑MS to ensure quality, purity and stability.
• Data‑Driven Innovation:
  Apply Quality by Design (QbD) and Design of Experiments (DoE) principles to identify critical process parameters.
• Collaboration:
  
  Work cross‑functionally with Project Management, Process Introduction, Analytical, and Quality teams during process development and transfer into clinical manufacturing.

• BSc/MSc/PhD in Chemistry, Biochemistry, Chemical Biology/Engineering or similar, with at least 10 years of relevant industry experience.
• In‑depth understanding and proven hands‑on experience with the conjugation of small molecules (cytotoxins, fluorochromes, chelators, oligonucleotides etc.) to antibodies and other proteins.
• Skilled in all aspects of downstream process development, including reactive chemistry.
• Experience in high‑throughput/parallel process and reaction screening, and process optimisation and validation for late‑phase / commercial scale.
• Knowledge of cGMP and EU, MHRA and FDA regulations, and experience with highly potent molecules and containment strategies.
• Proficiency in interpreting complex data using software such as Chemstation, Chromeleon, Design Expert.

• Excellent interpersonal skills and ability to explain technical concepts clearly to technical and non‑technical audiences.
• Proactive, inquisitive attitude with a focus on safety and continuous improvement.
• Attention to detail, problem‑solving skills, self‑motivation and a positive disposition.
• Strong organisational and planning skills with the ability to meet deadlines.
• Excellent oral and written communication skills.
• Ability to learn, share knowledge, and support team members in new manufacturing processes.
• Positive, resilient, and able to work under pressure with good humour.

A competitive salary, pension scheme, private healthcare, retail discounts through reward gateway, cycle‑to‑work scheme, 26 days annual leave and bank holidays, death‑in‑service coverage, on‑site health and wellbeing support, medical consultation and physiotherapy, 24/7 employee assistance program. Training and opportunities for further career development.

Equal opportunities statement:
Sterling Pharma Solutions is an equal opportunities employer and positively encourages applications from suitably qualified and eligible candidates regardless of sex, race, disability, age, sexual orientation, marriage or civil partnership, pregnancy or maternity, religion or belief.

Final date to receive applications: 03 Jul 2026