Senior Scientist

Senior Scientist – Downstream Process Development

One of our large bioprocessing clients is seeking a Senior Scientist to join their R&D team in King of Prussia, PA. This role is fully on site, 5 days/week and will lead downstream process development efforts focused on the chromatographic purification of monoclonal antibodies. This role is central to our clients mission of enabling large and small biopharmaceutical companies to bring transformative therapies to patients faster and more efficiently.

This individual will guide a small team (up to 6 reports) in designing and executing purification strategies that support late‑stage development and manufacturing readiness. The role is 50% hands‑on bioprocess development and 50% people management.

• M.S. in Biochemistry, Chemical Engineering, Biotechnology, or related field with 8 years of relevant industry experience, or Ph.D. with 5 years of experience in downstream process development for biologics.
• Demonstrated expertise in preparative chromatography and antibody purification.
• Proven ability to lead small scientific teams and manage lab operations.

• Hands‑on experience with AKTA systems, Unicorn software, and high‑throughput screening platforms (e.g., Tecan Te‑Chrom).
• Proficiency in analytical techniques such as HPLC, SDS‑PAGE, ELISA, UV spectroscopy.
• Familiarity with tech transfer, cGMP/cGLP standards, and regulatory documentation.
• Experience in client‑facing or CDMO environments is a plus.

• Design, execute, and analyze chromatography‑based purification processes (Protein A, ion exchange, HIC, etc.) for mAbs.
• Develop scalable, robust purification processes tailored to client molecules and manufacturing goals.
• Lead technology transfer activities to external manufacturing sites.
• Author technical reports, protocols, and support regulatory documentation.

Up to $135,000/year Base Salary. Exact compensation may vary based on several factors, including skills, experience, and education.

Employees in this role will enjoy a comprehensive benefits package starting on day one of employment, including options for medical, dental, and vision insurance. Eligibility to enroll in the 401(k)-retirement plan begins after 90 days of employment. Additionally, employees will have access to paid sick leave and other paid time off benefits as required under applicable law of the worksite location.

Mid‑Senior level

Full‑time

Science

Pharmaceutical Manufacturing