Senior Security Engineer (AI Safety), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

Isomorphic Labs (Iso Labs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning Alpha Fold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

As a Senior AI Security Engineer at Isomorphic Labs, you will operate at the absolute frontier of Artificial Intelligence and Cybersecurity. Reporting directly to the CISO, your mission is to architect, secure, and future-proof our pioneering AI-first platform and autonomous agentic workflows that drive the next generation of drug discovery pipelines.

In this high-impact role, you will design custom risk management frameworks tailored to the unique threat landscape of AI in life sciences, establish strict governance over critical model artifacts, and embed seamless security controls directly into distributed training and inference infrastructure. You will serve as the technical anchor bridging machine learning engineering, platform architecture, and adversarial defense.

Operating in a fast-moving, high-stakes environment, you will lead AI-specific incident response and pioneer model-driven defense mechanisms to automate threat hunting and mitigation. Your work will ensure that breakthrough scientific research is paired with an uncompromising, resilient defense safeguarding invaluable intellectual property while accelerating our innovation velocity.

• Adversarial Threat Modeling:
  Conduct cutting-edge threat modeling focused on AI/ML vulnerabilities, engineering a comprehensive risk management framework tailored to an AI-powered life sciences platform.
• Model Artifacts Protection:
  Partner with AI teams to establish a granular inventory, classification and protection framework for ML models’ weights, code, and training data.
• Agentic AI & LLM Guardrails:
  Design and deploy scalable guardrails, robust sandboxing, and real-time monitoring controls for our extensive LLM ecosystem, including ADK, MCP, and autonomous agentic workflows.
• Collaborative Security Engineering:
  Partner with ML researchers and platform engineers to design and implement robust security controls across the entire ML lifecycle—from data ingestion and training pipeline integrity to inference runtime controls.
• Model-Driven Incident Response:
  Act as the primary technical expert for AI security incidents, deploying advanced machine learning techniques to automate threat hunting, anomaly detection, and signatureless mitigation specific to LLMs.
• Compliance…