Principal Scientist - Lead Identification

PRINCIPAL SCIENTIST - LEAD IDENTIFICATION

The successful candidate will join an innovative Antibody Discovery and Engineering department with a strong record of success in developing novel antibody therapeutics in the field of immune-oncology and autoimmune diseases. We are looking for a motivated and talented scientist with deep understanding and strong hands-on experience in antibody display technologies, antibody expression and biophysical characterization to support the discovery of next generation MultispecificTM antibodies.

• Contribute to the development of antibody discovery platform by designing and generating novel antibody libraries for phage, yeast or mammalian display applications.
• Lead and perform antibody discovery campaign using phage, yeast or mammalian display.
• Perform high-throughput screening of antibodies using techniques such as surface plasmon resonance (SPR), ELISA, or flow cytometry.
• DNA sequence analysis of selected antibodies (Sanger or NGS)
• Clone, express, and purify therapeutic antibodies.
• Characterize antibody candidates using analytical methods (e.g. SDS-PAGE, SEC, DSF, AC-SINS, polyreactivity) and flow-cytometry.
• Develop and perform protein-protein interaction assays, including kinetic, epitope binning, blocking assays (ELISA, SPR, BLI)
• Participate in streamlining antibody discovery processes by implementing new technologies and adopting AI/ML.
• Effectively support projects and accomplish goals under project timelines.
• Interface with multiple discovery project and matrix teams across the organization
• Effectively communicate research progress and opportunities to senior management
• Support a culture that embraces scientific excellence, continuous learning, and increasing team’s ability to deliver novel drug candidates

• Ph.D. entry level or MSc degree in biotechnology, biochemistry or related discipline is required. At least 5 years of relevant industrial experience is preferred.
• Hands-on experience with protein engineering using display systems (phage, yeast or mammalian display) is required.
• Proficiency in molecular biology techniques (RNA extraction, RT-PCR, PCR, cloning, primer design) and DNA sequence analysis software is required.
• Experience with protein expression and characterization (e.g. SDS-PAGE, SEC) is required.
• Experience with protein-protein interaction technologies (e.g. SPR/BLI) would be a plus.
• Strong English communication skills, both oral and written
• Rigorous, excellent organization skills, autonomous, hands-on and team minded
• Strong interpersonal communication skills and the ability to present to all levels of the organization
• Proven experience in problem analysis/solving
• Proactive, reactive and adaptable

You will join us, a vibrant biotech community at the Biopôle (https://(Use the "Apply for this Job" box below).) overlooking the beautiful shores of Geneva lake in Lausanne, Switzerland.