Head of Information Technology

Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company developing cell therapies for patients suffering from autoimmune diseases. Guided by our core values, Stay True to Why, Collaborate to Accelerate, Lead with Clarity, Boldly Innovative, and Own the Outcome, we are committed to transforming the future of treatment for autoimmune disease. Join us at the forefront of cell therapy innovation and help redefine what’s possible.

Title :
Head of Information Technology
Reports to: CFO
Location :
Emeryville, CA (Hybrid) preferred or Remote with west coast hours

The Head of Information Technology leads the company’s technology strategy as it transitions from a development-stage biotech to a fully integrated commercial organization. Reporting to the CFO, this role is responsible for enterprise applications, cybersecurity, infrastructure, validation, data governance, IT operations, and digital enablement.

The Head of IT will build scalable, secure, and compliant technology capabilities that enable commercialization, regulatory readiness, and operational excellence. This leader partners closely with Commercial, Medical Affairs, Manufacturing & Supply, Quality, Regulatory, Clinical Development, Finance, HR, and Legal to align technology investments with business priorities.

This role also builds and leads a high-performing IT organization and manages key technology vendors and strategic partnerships.

Enterprise Technology Strategy & Leadership

• Define and execute a multi-year technology roadmap aligned with corporate and commercialization strategy.
• Serve as a senior advisor on technology strategy, investments, and risk.
• Establish governance, operating models, and decision frameworks to support scale.
• Lead IT strategy for transition to commercial operations, including launch readiness.

Commercialization & Business Systems Enablement

• Lead deployment of commercial systems (CRM, incentive compensation, territory alignment, analytics, omnichannel tools, etc.).
• Partner with Commercial leadership to enable field operations, customer engagement, and market access.
• Ensure integration of commercial platforms with ERP, HRIS, finance, and enterprise data systems.
• Drive enterprise application strategy across all business functions.

Enterprise Applications & Integration

• Own enterprise application strategy, implementation, integration, and lifecycle management.
• Develop scalable architecture supporting end-to-end business processes across all functions.
• Lead data governance, master data management, and enterprise reporting.
• Evaluate and implement technologies that improve efficiency and performance.

Cybersecurity, Risk & Compliance

• Lead enterprise cybersecurity, protecting IP, patient data, and regulated systems.
• Oversee IT risk management, business continuity, disaster recovery, and incident response.
• Ensure compliance with regulatory and internal control requirements.
• Partner with Legal, Quality, and Internal Audit on risk mitigation and audits.

Validation & GxP Systems

• Oversee validation strategy for GxP systems and regulated environments.
• Ensure inspection readiness and compliance with regulatory expectations.
• Partner with Quality and Regulatory on validation governance and documentation.

IT Operations & Infrastructure

• Lead infrastructure, cloud, networks, collaboration tools, and end-user computing.
• Ensure reliable and scalable global IT service delivery.
• Oversee service desk operations, ITSM, and continuous improvement.
• Define service levels and operational standards.

Talent & Organizational Leadership

• Build and lead a high-performing IT organization for a growing public biotech company.
• Develop leaders across cybersecurity, applications, infrastructure, and operations.
• Foster a culture of accountability, innovation, and service excellence.
• Align workforce planning with business growth.

Vendor & Financial Management

• Lead IT sourcing, vendor management, and strategic partnerships.
• Oversee IT operating and capital budgets.
• Ensure vendor performance and value delivery aligned to business goals.

• Bachelor’s degree in information systems, Computer Science, Engineering, Business, or related discipline.…