Research Fellow in Immunosuppressant Therapeutic Drug Monitoring

Do you have an interest in diagnostics applications? Would you like to be involved in a multidisciplinary project to develop an immunosuppressant therapeutic drug monitoring sensor to provide better patient care?

We are a multidisciplinary team of researchers focusing on the development of in vitro diagnostics assays and devices to deliver better therapeutic drug monitoring (TDM) – this can optimise antibiotic use which will help combat AMR, or ensure accurate dosing can be achieved where therapeutic windows are narrow such as in immunosuppressants – this will significantly improve health outcomes. In therapeutic drug monitoring, drug concentrations are measured in the body and the results used to guide dosing.

This is currently being done for immunosuppressants, but using mass spectroscopy which leads to long delays between sample taking and results being available. We have recently developed an assay for the rapid, accurate and cheap measurement of the immunosuppressant tacrolimus, which will enable routine use of therapeutic drug monitoring.

In this role, you will build on our recent advances and will further develop this assay for therapeutic drug monitoring of tacrolimus into a clinically deployable assay.

You will have a PhD in chemistry, chemical biology or related discipline and a strong background in in vitro diagnostics assay development and validation for clinical use.

A PhD in Chemistry, Chemical Biology or a closely allied discipline, A strong background in in vitro diagnostics assay development for clinical use, Industrial experience of in in vitro diagnostics, including generating analytical performance data to establish assay suitability for clinical application, Experience in independently developing, optimising and troubleshooting assays to deliver experimental decision-enabling strategies, Experience in handling and carrying out diagnostic assays on patient samples, Good time management and planning skills, with the ability to meet tight deadlines and manage competing demands effectively without close support, Excellent communication skills both written and verbal, experience in writing high-quality reports of industrial standard and synthesising complex scientific and technical information;

and the ability to communicate your work at national and international conferences, A proven ability to work well both individually and in a team, A strong commitment to your own continuous professional development

£25,877.80 to £34,240.03 per year, pro rata