Mechanical Systems Engineer

Cytonome

Cytonome is a biotechnology engineering and manufacturing company that designs and develops cutting edge optical-based cell sorting platforms. We offer powerful application-specific technologies for cell therapy, life science, and industrial markets. We work closely with our clients to understand their needs and provide their ideal solution.

This Opportunity is within our Lexington-based high-throughput cell sorting development team. The Systems Engineer will be directly involved in the design, assembly, testing, and optimization of our innovative high-throughput, microfluidic-based cell sorting platforms. The position will collaborate with a diverse technical team on product development both for R&D and cGMP operations. This role will have a direct impact on several globally important applications of our current and future cell isolation technologies.

• Work with a cross‑functional team of engineers and biologists to design, assemble and test complex electrical, mechanical, microfluidic, and optical systems
• Own the system design and drive automation algorithm development
• Conceptualize, design, procure, prototype, and build components and assemblies for products and testing/manufacturing fixtures
• Conduct root cause analysis on application‑specific issues reported by the client
• Troubleshoot and document problem resolution during system level testing
• Develop, execute, and document test protocols
• Communicate tradeoffs, program risks, and technical progress to the team and management
• Provide feedback and help generate test and assembly documentation for transfer to manufacturing

• Bachelor’s degree in mechanical engineering, or related engineering fields
• 3+ years in engineering environment
• Proficiency in CAD software (Solid Works) for designing complex assemblies with tight tolerances.
• Strong understanding of DFM/DFA (Design for Manufacturability/Assembly) principles.
• Hands‑on experience with rapid prototyping, GD&T/tolerance stack‑up analysis, and iterative design validation
• Excellent problem‑solving skills and a proactive mindset for identifying and resolving design‑to‑manufacturing challenges
• Strong communication skills and ability to document engineering processes clearly for tech transfer and scaling
• Ability to self‑organize and work effectively with limited supervision

• Experience transitioning products from R&D/prototype stage to pilot and scaled manufacturing.
• Experience with research instrumentation and/or flow cytometry
• Familiarity with microfluidic systems, optics, or electromechanical components is a plus.
• Experience with Python, LabVIEW, and Matlab is preferred

ST genetics® is an affirmative action EEO employer. We are an equal opportunity employer and all qualified candidates will receive consideration for all positions without regard to race, color, age, religion, sex (including pregnancy), sexual orientation, gender identity, national origin, veteran status, disability, genetic information, or any other characteristic protected by law.

ST genetics® is not currently accepting unsolicited resumes from search firms. Regardless of past practice, all resumes submitted by search firms to any employee at ST genetics® via‑email, the Internet or directly to hiring managers at ST genetics® in any form without a valid written agreement in place for that specific position will be deemed the sole property of ST genetics®. As a result, no fee will be paid in the event the candidate is hired by ST genetics®.