Senior Scientist , DMPK

Position: Senior Scientist I, DMPK
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.

Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform.  Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description Wave Life Sciences is seeking a highly motivated and detail-oriented Scientist with strong expertise in bioanalytical and Drug Metabolism and Pharmacokinetics (DMPK) sciences to support drug development programs from preclinical through clinical stages. The successful candidate will play a key role in independently designing, executing, and interpreting pharmacokinetic (PK), toxicokinetic (TK), plasma protein binding and in vitro drug-drug interaction (DDI) studies.

This role will be based in our Lexington, MA office with a hybrid work arrangement.

Experience Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or related discipline with at least 3 years of relevant experience, or M.S. with at least 6 years of industry experience

The ideal candidate will have experience supporting the development of RNA-based modalities (e.g., siRNA, antisense oligonucleotides, GalNAc conjugates, etc.)Responsibilities:
Independently design, execute, and interpret in vitro and in vivo studies (i.e., ADME, PK, PK/PD) to support advancement of RNA therapeutic programs

Autonomously analyze and interpret PK, TK and PK/PD data using appropriate software tools (e.g., Phoenix Win Nonlin), including conducting NCA and graphical exposure-response analyses

Represent DMPK function at cross-functional project team meetings

With guidance, plan, execute, and deliver DMPK deliverables from lead selection to IND stage

Collaborate with cross-functional teams including bioanalysis, discovery research, toxicology, clinical pharmacology, regulatory, and external CROs to meet program goals and timelines

Prepare high-quality scientific reports and integrate DMPK data into regulatory documents (IND, CTA, briefing documents, etc.)Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high-quality data Deliver robust IND/CTA-enabling DMPK packages to support regulatory filings

Stay current with regulatory guidance and scientific advances in the field of bioanalysis and DMPKKey Skills Proficient in PK software tools such as Phoenix Win Nonlin and conduct NCAConduct graphical analysis using standard tools like Phoenix Win Nonlin, R, or similar

Demonstrate sound knowledge of PK/PD principles

Familiarity with regulatory requirements for nonclinical DMPK studies

Demonstrate expertise in plasma protein binding and in vitro DDI assessments (e.g., CYP inhibition/induction, transporter interactions)
Ability to innovate and think creatively to support the drug development process

Excellent communication, organizational, and teamwork skills

Knowledge and experience in bioanalysis to support DMPK studies (metabolite identification, biodistribution, etc.)Hands-on experience with modeling and…