Formulations, Oligonucleotide Synthesis and Chemistry Co-op

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.

Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Wave Life Sciences seeks a highly motivated co‑op student to join its team of Small Scale Synthesis, Oligonucleotide Synthesis and Chemistry scientists in Lexington, Massachusetts. This co‑op student will gain exposure to areas of oligonucleotide synthesis, formulation, purification, and analysis. The co‑op will be trained in a variety of laboratory techniques and instrumentation, making this an excellent learning opportunity for future entrance into industry or academia.

This is an ideal position for any student with strong organizational skills and attention to detail who thrives in a team-oriented, fast-paced and multi-disciplinary biotech environment. Completion of coursework in organic chemistry required with biochemistry, analytical chemistry and laboratory experience is preferred. This is an ideal position for an individual with an interest in analytical chemistry who thrives in a team-oriented, fast-paced, biotech environment.

This candidate will be responsible for fulfilling compound requests to support Discovery-related activities and ensuring sample quality.

• Analyze oligonucleotides by LC-MS, UHPLC, endotoxin, osmolality, UV and pH
• Prepare/formulate oligonucleotide samples for in vitro and in vivo biological assays and method development
• Use automated liquid handler (Hamilton Star) for high throughput plate-based sample preparation
• Assist with management of the oligonucleotide inventory and re-QC program
• Record and present data in an electronic laboratory notebook (ELN)
• Gain exposure to automated oligonucleotide solid-phase synthesis techniques
• Gain exposure to liquid chromatography method development and application

• Currently enrolled in an undergraduate or graduate science programin Chemistry, Biology, Biotechnology or related field
• Coursework in organic chemistry is required, biochemistry and analytical chemistry is a plus
• Understanding of laboratory best practices and safety protocols
• Attention to detail and well organized
• Laboratory experience with common laboratory operations including pipetting, weighing, and centrifugation preferred
• Enthusiasm for DNA/RNA therapeutic development

Pay Range Disclosure Statement: $24 USD - $30 USD

The range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity. This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives.

In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed…