Scientist II, Bioanalytical and Biomarker Development

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology.

Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform.  Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description:

Wave Life Sciences is seeking a highly motivated individual to join the Preclinical and Clinical Development Sciences team in Lexington, Massachusetts. The Scientist II, Bioanalytical and Biomarker Development will support the clinical stage program teams aiming to deliver bioanalytical data and reports, which directly support toxicology, PK/PD studies in preclinical settings through clinical studies. In addition, this individual will support target engagement, PK/PD and tolerability studies in preclinical settings.

Experience:

B.S. / M.S. and 8 or more years relevant experience in industry

Responsibilities:
May include some or all of the following:

Perform method development and qualifications for oligos in biological matrix using LC-MS/MS, MSD and/or ELISA based assays

Perform sample analysis according to established method protocols in different biological matrix, e.g. blood, plasma, tissue etc.

Involved in planning experimental design and execution of all aspects of bioanalysis, efficient assay development to support investigative Tox and PK studies

Transfer methods to CROs and manage their work Adept at preparation of clear and accurate reports for internal and external projects

Prepare clearly articulated experimental reports and data presentations

Key

Skills:

Hands on experience across bioanalytical and biomarker assay development and qualification using multitude of bioanalytical methods (i.e., ELISA, MSD, LC-MS, RT-PCR, qPCR, and cell-based assays) to support discovery, preclinical and potential clinical projects

Experience with transfer of assays to CROs (or prior experience within bioanalytical CROs) and troubleshooting technical issues

Ability to independently analyze data and present and share the data with the stakeholders

Conversant with writing SOPs and other technical reports as needed

Experience with in a start-up or small biotech environment

Excellent organizational and communication skills, with an ability to embrace change and multi-task in an extremely fast paced environment

Excellent problem-solving skills and ability to work as a team player in a dynamic environment

Pay Range Disclosure Statement $135,000—$182,000 USDThe range provided is based on what we believe is a reasonable estimate for the annual base salary pay range for this position at the time of posting. Actual annual base salary will vary based on several factors including, but not limited to, relevant skills, experience, qualifications, position criticality, and internal equity.  This position is eligible for a discretionary annual bonus and discretionary stock-based long-term incentives.  

In addition to compensation, Wave offers a comprehensive and competitive range of benefits designed to support our…