Senior Research Associate - In Vivo Pharmacology

Facility:
Research

Location:

Lexington, MA, US

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Plainsboro reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas.

We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

We are seeking a highly motivated and scientifically curious Senior Research Associate to advance early drug discovery through high-quality, hands‑on in vivo research. The ideal candidate brings strong technical skills, thoughtful experimental judgment, and enthusiasm for understanding the biology behind the data. The candidate will be responsible for design, execute, analyze, coordinate and report pre‑clinical pharmacokinetic and pharmacodynamic in vivo experiments within research projects as part of target validation, target maturation, or mode‑of‑action studies.

Additional responsibilities include develop and improve in vivo models supporting non‑clinical studies, take an active role in research projects and contribute to innovation by identifying and exploring new therapeutic targets and principles. Communicate evaluations and implications of in vivo data internally, externally and in regulatory submissions as relevant. Demonstrates some subject matter knowledge. Sets and achieves day‑to‑day operations with some impact on others within or outside the unit.

Works on problems of limited scope. Follows standard practices and procedures in analyzing situations or data from which answers can be readily obtained. Normally receives general instructions on routine work and detailed instructions on new projects or assignments. Might require guidance from manager/senior colleagues. Hands‑on work of increasing complexity; responsibility for experimental planning, execution & analyses with limited supervisor input;

manages personal experimental timelines to meet deadlines for project with input from supervisor; may present ideas or data to team, site, or global project team; develops, optimizes & drafts protocols for methods of moderate complexity with reduced input from supervisor; contributes to formal study reports & study protocol drafting & review; may mentor junior staff.

Reports to the head of the related research area and may be supervised by a Scientist. This position will interact with the related research area team members and other research groups at Novo Nordisk, as well as global internal stakeholders and external research collaborators. This position will function as an individual contributor.

• Contribute to hypothesis‑driven study designs, including selection of appropriate models, controls, doses, sampling schedules, and endpoints.
• Plan and execute mouse studies, including animal handling and restraint; oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) dosing; body‑weight measurements; in‑life and terminal blood collection; necropsies; and tissue collection.
• Coordinate study activities, materials, and timelines with internal teams and external collaborators.
• Monitor animal health and welfare, recognize unexpected findings, and communicate concerns promptly.
• Conduct all work in accordance with approved…