Principal Statistician

Principal Statistician – Evidence Synthesis & HTA

Location: Oxfordshire or London
Sector: HEOR / Evidence Synthesis / HTA
Type: Permanent, full-time

Our client is seeking a Principal Statistician to lead complex evidence‑synthesis programmes and guide statistical strategy across high‑impact HTA and market access projects. This role offers substantial influence, technical leadership, and the opportunity to shape methodologies within a collaborative, methodologically focused team.

As a Principal Statistician, you will own the design, delivery, and interpretation of statistical components across multiple evidence‑synthesis and HTA projects. You will partner closely with multidisciplinary teams while providing direction and mentorship for developing statisticians.

Key responsibilities include:

• Designing statistical analysis plans and feasibility assessments for advanced evidence‑synthesis challenges.

• Coding and running analyses including pairwise meta‑analysis, NMAs (including time‑varying survival models), MAIC/PAIC, and individual patient data analyses.

• Overseeing quality control processes to ensure methodological rigour and reproducibility.

• Communicating complex statistical results clearly to clients and cross‑functional teams.

• Leading contributions to proposals, pitch presentations, and development of internal methodologies, SOPs, and QC frameworks.

• Providing technical leadership, coaching, and mentorship to junior and mid‑level statisticians.

You bring depth of experience in evidence synthesis and thrive in roles that blend analytical excellence, leadership, and intellectual ownership. You enjoy shaping projects, influencing decision‑making, and raising the statistical bar within a team.

Essential experience:

• Master’s degree or PhD in a quantitative discipline.

• Significant experience leading evidence‑synthesis statistical work (meta‑analysis, NMA, indirect comparisons).

• Proficiency in R, with familiarity in Bayesian approaches (e.g., BUGS).

• Strong track record in HTA‑focused analyses and interpreting results for health economic models and submissions.

• Experience leading or mentoring statisticians and influencing analytical approaches.

• Clear and confident communication of complex statistical concepts to diverse audiences.

Desirable:

• Experience with advanced NMA developments (e.g., ML-NMR).

• Experience delivering training or statistical learning initiatives.

• Consultancy experience managing multiple projects simultaneously.

You’ll join a supportive, engaging environment where quality, curiosity, and development are central. Expect:

• A flexible working culture with genuine autonomy.

• Regular interaction with senior leadership and the chance to shape internal methodologies.

• Broad exposure across therapeutic areas and diverse HTA‑focused projects.

• The influence and visibility expected of a true Principal‑level role.