Senior Medical Director, Oncology Clinical Development - Sarcoma

Location: Greater London

For candidates seeking to be located at our Stevenage site, this role will temporarily be based ever, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029 .The

Senior Medical Director, Oncology Clinical Development – Sarcoma, is a senior physician leader within the clinical programme team, providing medical oversight, strategic clinical insight, and a patient-centred perspective across the design, conduct, and interpretation of clinical studies. This role ensures that medical considerations, patient safety, and clinical integrity are consistently applied across studies within a programme.

Operating within the clinical strategy defined by the Clinical Development Lead (CDL), the Senior Medical Director partners closely with the Senior Scientist and cross-functional teams to guide the integration of physician expertise into study execution and programme-level decision-making. The role serves as a senior member of the Clinical Matrix Team (CMT), contributing to complex clinical decisions, regulatory interactions, and external scientific engagement.

The Senior Medical Director provides matrixed oversight to the clinical team within the programme, supporting consistency of clinical judgement, safety evaluation, and medical interpretation across studies.

PLEASE NOTE:

This career opportunity requires an on-site office presence (minimum of two days a week) at one of GSK’s Switzerland (Zug), UK (Stevenage or London HQ) or US (PA or MA)  This Role You Will:

Serve as a senior physician leader within the clinical programme, providing medical oversight and clinical insight across study design, conduct, and data interpretation

Provide guidance on medical monitoring and safety oversight across studies, ensuring consistent application of clinical judgement and patient safety standards

Interpret complex clinical and safety data, generating insights that inform programme-level decisions led by the CDLPartner with the Senior Scientist and cross-functional teams to ensure medical considerations are integrated across study execution and programme delivery

Provide senior medical input into protocol development and study design, ensuring clinical relevance and patient-centred design within the clinical strategy defined by the CDLServe as a senior member of the CMT, influencing study-level and programme-level decision-making

Engage with investigators, Key External Experts (KEEs), and scientific leaders to support external engagement and represent the programme at advisory boards, steering committees, and scientific forums

Provide medical guidance and mentorship to Medical Directors within the programme, supporting consistency and development of clinical capability

Detailed Responsibilities:

Medical Monitoring and Safety Oversightconsistency in approach, patient safety, and protocol adherence

Guide interpretation of safety data in collaboration with pharmacovigilance, supporting signal detection, escalation, and benefit–risk evaluation across the programme

Participate in and contribute to safety review forums (e.g., SRT, IDMC), providing senior physician perspective on complex safety questions

Ensure medical monitoring approaches are aligned across studies and consistent with regulatory and organisational standards

Study Design and Execution Provide senior medical input into protocol development across studies, ensuring clinical relevance, feasibility, and alignment with the clinical strategy defined by the CDLGuide clinical aspects of study design and protocol implementation, particularly for complex, high-risk, or…