Senior Scientist

Role: Senior Scientist – Process Development

Company: ATMP focussed biotech

Location: London, on-site

Full time / Permanent

We are currently supporting an innovative clinical-stage biotechnology company developing next-generation engineered immune-cell therapies targeting severe diseases.

This is an exciting opportunity for an experienced and highly motivated scientist to join a multidisciplinary Process Development team focused on development of advanced cell therapy manufacturing platforms for clinical application.

The successful candidate will play a key role in driving process development activities for engineered-cell therapy programmes progressing through clinical development, alongside supporting platform expansion into additional therapeutic indications.

The role will be highly laboratory-based and collaborative, involving close interaction with discovery, translational, manufacturing, quality and clinical teams, as well as external partners and CDMOs.

• Driving development and optimisation of cell therapy manufacturing platforms for clinical application
• Designing and executing process development experiments and analysing complex datasets
• Supporting development and optimisation of engineered-cell workflows involving mRNA/nucleic acid delivery technologies
• Contributing technical expertise around transfection, non-viral engineering and engineered immune-cell process optimisation
• Supporting process robustness, manufacturability and scalability activities
• Technology transfer of manufacturing processes into GMP manufacturing environments
• Supporting regulatory and quality documentation activities
• Cross-functional collaboration with internal scientific teams and external partners
• Supporting development of manufacturing workflows for late-stage clinical programmes
• Contributing to continual improvement of process understanding, data collection and process performance
• Supporting and mentoring junior scientists where appropriate

We are particularly interested in candidates with hands-on experience across areas such as:

• Transfection / electroporation / nucleofection
• Non-viral engineering approaches
• Engineered immune cells (CAR-T, CAR-NK, macrophages etc.)
• LNP or nucleic acid delivery systems
• Translational cell therapy or CGT process development
• Technology transfer and interaction with external manufacturing partners/CDMOs

• BSc, MSc or PhD in Cell Therapy, Immunology, Molecular Biology, Biotechnology or related field
• Industrial experience within process development, cell therapy, gene therapy or advanced therapeutics
• Strong laboratory and experimental design capabilities
• Experience working within multidisciplinary project teams
• Understanding of translational development and manufacturing considerations within advanced therapies
• Excellent communication and presentation skills

Previous experience across GMP manufacturing, regulatory submissions, process validation or late-stage clinical development would be advantageous.