Senior Business Applications Manager

Location: Greater London

## Senior Business Applications Manager Apply locations:
UK - London, White Citytime type:
Full time posted on:
Posted Todayjob requisition :
JR100104
** Work with us
** Our team are passionate in the pursuit of excellence and in pushing the boundaries of cancer therapy and Autoimmune disease to deliver life-changing treatments to patients.

Whilst working at Autolus you will enjoy a flexible, diverse and dynamic working environment which actively promotes creativity, leadership and teamwork – together we are ONE Autolus.
*
* Job Description:

*
* Job Title:

Senior Applications Manager (Corporate & Commercial Applications)
Reports to Senior Director, Application Management Department: IT

Hours:

Monday – Friday (core office hours)

Location:

Mediaworks (London) Hybrid working with occasional travel to Stevenage
** About Autolus
** Autolus is a biopharmaceutical company, advancing innovative therapies at both clinical and commercial stages of development, focused on next-generation, programmed T cell therapies for the treatment of cancer. Using a broad suite of proprietary and modular T cell programming technologies, the company is engineering precisely targeted, controlled, and highly active T cell therapies designed to better recognize cancer cells, break down their defence mechanisms, and eliminate these cells.

Autolus has a pipeline of product candidates in development for the treatment of haematological malignancies, solid tumours, and autoimmune diseases.
** Why Autolus
** Our team is passionate in the pursuit of excellence and in pushing the boundaries of cancer therapy and autoimmune diseases to deliver life-changing treatments to patients. Whilst working at Autolus you will enjoy a flexible, diverse, and dynamic working environment which actively promotes creativity, leadership and teamwork. In addition to this Autolus is proud to offer a competitive salary, performance related bonus as well as a comprehensive benefits package.
** Our Promise
** Autolus is developing complex, breakthrough therapies for a globally diverse market and equally recognises that diversity amongst our people is critical to our mission. As we draw on our differences, what we’ve experienced, and how we work, we celebrate diversity and are committed to creating an inclusive environment for all employees.
** Role Summary
** The Senior Applications Manager is responsible for owning and overseeing a portfolio of enterprise applications, including systems such as CRM, ERP, HRIS, and their associated integrations, which support key corporate and commercial business functions.

This role is accountable for ensuring that these applications consistently deliver reliable, high-quality, secure, and cost-effective outcomes for the organisation. While not directly responsible for day-to-day support operations, the role provides strategic direction to service delivery teams and holds them accountable for performance, service quality, and adherence to agreed SLAs and operational standards.

A key aspect of the position is maintaining oversight of application health, performance, resilience, and stability across the portfolio, ensuring systems remain fit for purpose, compliant, and aligned with evolving business needs. The role is also responsible for establishing, maturing, and embedding effective governance frameworks and operational rhythms that support the ongoing health, stability, and continuous improvement of applications within a BAU environment.

This includes implementing structured review cadences, service governance forums, risk and issue management processes, change oversight, vendor performance management, and KPI reporting mechanisms to drive operational excellence and accountability across the application landscape.

The Senior Applications Manager will chair or contribute to governance forums and ensure appropriate controls, policies, and standards are implemented across the application portfolio. This includes ensuring that application changes are assessed, prioritised, approved, and delivered in line with business priorities, regulatory expectations, cybersecurity requirements, and IT governance standards.

The role works closely with business stakeholders to understand strategic priorities, shape demand, and ensure application roadmaps, investment decisions, and enhancement activities are aligned with organisational objectives. In addition, the role acts as a key escalation and decision-making point for application-related risks, issues, technical debt, and continuous improvement opportunities across the portfolio.
** Key Responsibilities
**** Support Oversight (via Service Delivery)
*** Partner with Service Delivery Managers (SDMs) and support teams to ensure strong application support performance
* Define expectations for support quality, SLAs, and user experience
* Review incident trends and ensure systemic issues are identified and resolved
* Hold vendors and support teams accountable for outcomes, not just activity
** Business Partnering and Demand…