Bioanalytical Lead

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights faster breakthroughs and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one were building today. It starts with the culture at this company. It starts with you.

Isomorphic Labs (Iso Labs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning Alpha Fold system. Since then our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AIs powerful capabilities we can use it to model complex biological phenomena to help design novel molecules anticipate how drugs will perform and develop innovative medicines to treat and cure some of the worlds most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day and with each new breakthrough were getting closer to the promise of digital biology and achieving our ambitious mission to one day solve all disease with the help of AI.

Your mission

We are seeking a highly innovative and experienced Bioanalytical Lead to bridge the gap between our predictive AI design platform and wet-lab preclinical execution.

In this role you will define the overarching bioanalytical strategy across our expanding portfolio covering small molecules advanced biologic formats and Antibody-Drug Conjugates (ADCs) in both non-GLP and GLP environments. You will collaborate closely with the drug design teams design robust bioanalytical assays manage global Contract Research Organizations (CROs) and lead the logistical execution required to rapidly advance our candidates toward IND submission.

As the Bioanalytical Lead you will serve as the technical expert for our diverse portfolio of computationally designed therapeutic candidates. As part of the preclinical development function this is a high-impact leadership role responsible for building the bridge between Isomorphics AI-driven discovery engine and the effective execution of our robust preclinical strategies alongside safety and DMPK. The successful candidate will be forward thinking thrive in fast-paced agile environment and ready to embrace Isos AI-first mindset and challenge the status quo.

With a broad range of internal and external stakeholders candidates will be expected to have exceptional communication and influencing skills.

• Define and execute comprehensive bioanalytical strategies for small molecules large molecules and complex modalities (ADCs) from discovery through preclinical development covering both non-GLP and GLP environments.
• Oversee the design validation and transfer of robust PK PD and immunogenicity (ADA) assays at external labs.
• Collaborate with AI/machine learning scientists to integrate bioanalytical data back into predictive models helping to continuously improve our platforms accuracy.
• Lead biomarker assay strategies utilizing both traditional approaches and AI-identified novel biomarkers to support preclinical proof-of-concept.

• Select qualify and manage a high-performing network of global CRO partners ensuring rigorous data quality strict timelines and budget alignment.
• Master complex global logistics including international sample shipments cold-chain…