Postdoctoral Research Associate - Internal - Strand WCR LS

The GSTT Asthma Service based at Guy’s Hospital is home to the largest cohort of severe asthma and EGPA patients receiving biologic therapies in the UK offering a unique opportunity to take part in translational research in these diseases.

The Jackson Lab within the Peter Gorer Department of Immunobiology, SIMS is focussed on (i) exploring the role of eosinophilic and T2 inflammation in asthma and related conditions both in the stable state and during exacerbation (ii) understanding the mechanisms that underpin the heterogeneity in response to anti-T2 therapies in asthma and conditions including EGPA and eosinophilic pneumonia.

Over the last 5 years the Jackson Lab has obtained over £5m in grant funding and published over 50 original research manuscripts

This role is for a scientist who has obtained a PhD and has already accumulated some post-doctoral experience in the field of type 2 immunity as applied to asthma and related upper and lower airway conditions. The applicant should have a thorough understanding of respiratory immunology and particularly eosinophilic and T2 immune pathways including mast cell, Th2, ILC2 and epithelial related processes in asthma.

It is expected that the scientist has first-hand experience of processing and analysing airway samples including cell culture.

The successful candidate will have a thorough understanding of respiratory immunology and particularly eosinophilic and T2 immune pathways in diseases such as asthma. The scientist should have first-hand experience of processing and analysing airway samples including cell culture.

The successful applicant will be joining a well-established and highly productive clinical and translational asthma research group at King’s College London based on the Guy’s Hospital Campus. The Jackson Lab is closely integrated into the regional NHS Severe Asthma and EGPA clinics allowing access to airway and blood samples from a large cohort of patients.

This group has led on several large multicentre phase 3 and phase 4 clinical trials of biologic therapies in asthma as well as real world studies of biologic therapies in both asthma and EGPA.

The applicant will work alongside clinical fellows undertaking mechanistic projects in severe asthma as well as other post-doctoral scientists working in this group. They will lead on several aspects of ongoing mechanistic projects aligned to phase 3 and phase 4 clinical trials of biologic therapies in asthma.

This is a full time post 35 hours per week, and you will be offered a fixed term contract until 31/12/27.