Senior Research & Operations Technician

Job Summary

Location: London

Reporting to: Executive Director, Translational Research

Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England, and its U.S. headquarters in Boston, Massachusetts. This role is based in the heart of London in the Research facility of our Hammersmith headquarters.

The Senior Research & Operations Technician will be responsible for two main activities within the Translational Research team: oversight and management of core Lentiviral vector and Cell & Gene therapy analytical methods, and provision of operational laboratory management to support the wider Translational Research & Development teams. The role requires deep expertise in molecular biology and analytical methods, preferably with experience of Lentiviral vector production and working within the cell & gene therapy field, in order to lead and support staff responsible for the provision of core technical LVV production & analytical services.

Candidates should also have experience of research laboratory management, with previous responsibility for the implementation of quality and safety practices in a research setting. The Senior Research Operations element of the role will provide guidance, training and mentorship to colleagues within the department on policies, procedures and best practices for an organized and effective working environment to support and optimise productivity for the research.

The Senior Research & Operations Technician will work closely with Translational Research Leadership, Facility Management and Global Technical Operations Leadership to develop and implement policies and procedures within Orchard’s R&D facility. This will include monitoring, ensuring compliance and working towards continuous improvements in research quality, data integrity and laboratory practices.

• Senior administrative and technical role responsible for enabling and optimising daily operations and infrastructure of Orchard’s research laboratories to support the strategic goals of the R&D teams.
• Provide line management of the Translational Research Core Technical team, including allocation of assignments, training and development of technical staff.
• Oversee the coordination of core Molecular Biology, Vector and Analytical activities provided for the Translational Research department to align vector designs with production requirements, working with dedicated technical staff, and where required contribute directly to the delivery of:
• Vector Design & Assembly:
  Generating and validating novel lentiviral vectors for ex vivo or in vivo therapeutic applications, using expertise in molecular biology, CRISPR, PCR, qPCR/ddPCR, molecular cloning, western blotting, and mammalian cell culture.
• Production & Optimization:
  Producing lentivirus, optimising protocols and improving purification processes to improve yield.
• Analytical Testing:
  Performing assays to assess viral titer, potency, transduction efficiency and purity, and developing standardized protocols for vector performance.
• Core LLV and Analytical Team Leadership:
  Providing expertise to support technical research staff, troubleshooting, updating protocols, and ensuring regulatory compliance.
• Implement rigorous experimental design, statistical analysis, and documentation to ensure reproducibility, traceability, and data integrity.
• Oversee the achievement and maintenance of high-quality robust standards of research, and the day-to-day operations of research laboratories, ensuring a safe and organized work environment, efficient workflows and maintenance, training and where required, operation and management of critical research & analytical equipment.

• Coordinate with the Facility Management team and IT to ensure smooth lab functioning, adherence to company policies, and support with equipment management, Health & Safety implementation and standards of working practices.
• Provide…