Research Fellow - Mouse Electrophysiologist

Overview

The Nascimento Research Group is a newly established laboratory within the Department of Neuromuscular Diseases, focused on translational neuroscience and the study of spinal motor circuit neurophysiology in both animal models of disease, including ALS, and in human patients. The group uses a range of electrophysiological approaches in rodents alongside high-density surface electromyography (HDsEMG) in humans.

• Study neuromuscular and spinal circuit pathophysiology in mouse models of Amyotrophic Lateral Sclerosis (ALS).
• Characterise the time‑course of alterations in spinal microcircuits, motoneurons, neuromuscular junctions, and muscle.
• Determine how these changes impact motor behaviour in mouse models of ALS.
• Employ neurophysiological recording techniques in mice, including in vitro motoneuron recordings from spinal cord preparations, in vivo motoneuron recordings from intact animals, and ex vivo neuromuscular junction recordings from nerve‑muscle preparations.
• Analyse data using appropriate statistical methods and prepare findings for publication.

• PhD in a Neuroscience-related discipline (or be near completion) with experience in electrophysiology, in vitro patch clamp recordings and/or in vivo recordings.
• Good understanding of neuronal physiology and single‑cell electrophysiology.
• Proven ability to critically evaluate experimental results and analyse data using appropriate statistical methods.
• Evidence of a good publication record and a solid quantitative background with proficiency in data analysis and statistics.

Starting salary offered at £41,103 per annum, inclusive of London Allowance.

Appointment as Research Fellow is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be as Research Assistant with salary £39,148–£41,833 per annum, with appointment as Research Fellow being backdated to the date of final submission of the PhD thesis.

Benefits include access to the university benefits page: