Research Scientist, Radiobiology

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development.

The company is evaluating nuzafatide pevedotin (formerly 5528), a Bicycle Drug Conjugate (BDC) targeting EphA2, a historically undruggable target; zelenectide pevedotin (formerly BT8009), a BDC targeting Nectin‑4, a well‑validated tumor antigen; and BT7480, a Bicycle Tumor‑Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin‑4 and agonizing CD137, in company‑sponsored clinical trials. Additionally, the company is developing Bicycle Radio conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit

Culture is key and all Bicycle employees actively embrace and role‑model our company values:

• We are Dedicated to our Mission
  . You can’t change the world if you don’t have determination.
• We are One Team
  . We only succeed when we work together.

Your mission is to apply your skills in radio biology to support the preclinical development of our innovative Bicycle Radio‑Conjugates (BRCs). You will conduct key in vitro and in vivo experiments, generating the high‑quality data needed to understand the efficacy and mechanism of action of our next‑generation cancer therapies.

Working location:
This is a hybrid position with the majority of attendance at our office in London (up to 4 days per week), in the vicinity of Kings Cross, with an ongoing requirement to visit the Cambridge Office up to 2 days per month.

• Conduct in vitro and in vivo studies to evaluate the efficacy, mechanism of action, and radiobiological effects of our BRCs, following established study designs.
• Perform a range of assays to probe DNA damage response, cell cycle effects, and mechanisms of cell death.
• Characterize the effects of targeted radionuclide therapy on both tumour cells and the tumour microenvironment.
• Support radio biology research conducted through CROs and academic collaborations by assisting with material transfer and data organization.

• Diligently document all experimental work and clearly communicate results to your manager and project team.
• Contribute to the identification of potential pharmacodynamic biomarkers through careful experimental work.
• Contribute to scientific publications and conference presentations through your data generation and analysis.

• Core Expertise: You apply solid scientific knowledge to plan and conduct radio biology experiments with growing independence.
• Data / Insight: You interpret experimental results, identifying trends and drawing clear conclusions from your data.
• Knowledge Sharing: You share your expertise and observations with peers to build the team’s collective capability.

• Task / Project Delivery: You deliver work of moderate complexity independently, taking ownership of your assigned experiments and ensuring reliable results.
• Problem‑Solving: You adapt established methods to address new scientific challenges and troubleshoot issues in your experiments.
• Strategic Impact: You contribute key insights and reliable data that support team decision‑making on a project level.
• Autonomy: You work independently on defined projects with limited oversight on routine work.
• Decision‑Making: You select appropriate methods to achieve experimental objectives and deliver high‑quality data.
• Leadership / Mentorship: You provide guidance to less experienced colleagues, sharing…