Senior Scientist

Overview

GSK is a science‑led global healthcare company with a special purpose: to help people do more, feel better, live longer. We are on an audacious journey to impact the health of 2.5 billion people over the next decade. Our R&D division is at the forefront of this mission, dedicated to the discovery and development of groundbreaking vaccines and medicines. We are transforming the landscape of medical research by integrating cutting‑edge science and technology and harnessing the power of genetics and new data.

By fostering a collaborative environment that unites the talents of our people, we are revolutionising R&D to pre‑empt and defeat diseases. Join us in our commitment to uniting science, technology, and talent to get ahead of disease together.

Part of R&D, Large Molecule Research is accountable for the discovery of antibodies and other protein‑based therapeutics from the initial discovery, expression and characterisation to molecular engineering and biophysical profiling. Within Large Molecule Research, the Molecular Design and Engineering (MDE) group is responsible for antibody engineering and develop ability profiling to improve molecule quality and transform discovered leads into potential therapeutics before candidate selection.

We are seeking an analytical scientist to join the develop ability team within MDE. The role will be lab‑centric and will involve profiling / characterising a panel of biopharmaceuticals based on their biophysical properties, interpreting the data and conveying the outcomes to early project teams.

The successful candidate will have experience with one or more of the biophysical techniques such as dynamic light scattering, analytical size exclusion, differential scanning fluorimetry etc. and ideally have applied these to characterise the stability and/or structure of proteins. Although predominantly lab‑based the role will also require effective communication (both written and oral), organisational, interpersonal and teamwork skills.

• Execute molecular biology experiments, including gene knock‑in/knock‑out, viral transduction, and transfection, following established protocols and study plans.
• Communicate experimental outcomes to non‑experts on multi‑disciplinary project teams.
• Perform routine mammalian cell culture and maintain cell models required for ongoing studies.
• Support the design and optimisation of experiments in collaboration with project team members.
• Generate and analyse data from cell based assays to support project progression.
• Assist in the development and optimisation of assays relevant to proximity inducing small molecule programmes.
• Contribute to studies involving related modalities where appropriate, including antibody drug conjugates.
• Document experimental work clearly and maintain accurate records in line with GSK standards.
• Work collaboratively with scientists across disciplines to deliver project objectives.
• Communicate experimental results through team discussions and written summaries.

• PhD or equivalent academic/industry experience in biophysics or related discipline.
• Demonstrated, hands‑on experience characterising proteins using one or more of the following biophysical techniques: dynamic light scattering, analytical size exclusion or other chromatography based methods, differential scanning fluorimetry, mass spectrometry etc.
• Good analytical and data interpretation skills.

• Experience in working with automated liquid handlers.
• Familiarity with antibody drug discovery processes.
• Experience characterising protein‑protein interactions using surface plasmon resonance.

GSK is an Equal‑Opportunity/Affirmative‑Action Employer. All qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.