Research Scientist, Radiobiology

Job Description

Your mission is to apply your skills in radio biology to support the preclinical development of our innovative Bicycle® Radio‑Conjugates (BRCs™). You will conduct key in vitro and in vivo experiments, generating the high‑quality data needed to understand the efficacy and mechanism of action of our next‑generation cancer therapies.

Working location: This is a hybrid position with the majority of attendance being at our office in London (up to 4 days per week), in the vicinity of Kings Cross, with an ongoing requirement to visit the Cambridge Office up to 2 days per month.

Scientific & Project Execution

• Conduct in vitro and in vivo studies to evaluate the efficacy, mechanism of action, and radiobiological effects of our BRCs, following established study designs.
• Perform a range of assays to probe DNA damage response, cell cycle effects, and mechanisms of cell death.
• Characterize the effects of targeted radionuclide therapy on both tumour cells and the tumour microenvironment.
• Support radio biology research conducted through CROs and academic collaborations by assisting with material transfer and data organization.

Data Analysis & Communication

• Diligently document all experimental work and clearly communicate results to your manager and project team.
• Contribute to the identification of potential pharmacodynamic biomarkers through careful experimental work.
• Contribute to scientific publications and conference presentations through your data generation and analysis.

Knowledge & Expertise

• Core Expertise: You apply solid scientific knowledge to plan and conduct radio biology experiments with growing independence.
• Data / Insight: You interpret experimental results, identifying trends and drawing clear conclusions from your data.
• Knowledge Sharing: You share your expertise and observations with peers to build the team's collective capability.

Job Complexity

• Task / Project Delivery: You deliver work of moderate complexity independently, taking ownership of your assigned experiments and ensuring reliable results.
• Problem‑Solving: You adapt established methods to address new scientific challenges and troubleshoot issues in your experiments.
• Strategic Impact: You contribute key insights and reliable data that support team decision‑making on a project level.

Independence

• Autonomy: You work independently on defined projects with limited oversight on routine work.
• Decision‑Making: You select appropriate methods to achieve experimental objectives and deliver high‑quality data.
• Leadership / Mentorship: You provide guidance to less experienced colleagues, sharing your knowledge of specific assays and techniques.

Values & Behaviours

One Team

• Collaboration: You work constructively within and across teams to ensure your work is aligned with project goals.
• Inclusive Leadership: You encourage input from colleagues with different perspectives to enhance the quality of your work.
• Mentorship / Support: You actively share knowledge and offer support to your peers.

Adventurous

• Innovation: You suggest new approaches to experiments or improvements to existing assays.
• Risk‑Taking: You learn from experimenting with novel methods and are willing to try new techniques.
• Change Leadership: You support the team's transition to new processes or technologies.

Dedicated to our Mission

• Accountability: You take ownership for the quality and reliability of your experimental results.
• Resilience: You remain focused and determined when experiments do not go as planned.
• Inspiration: You demonstrate commitment by linking your daily work to our mission of helping patients.

• A strong educational background in radio biology, cancer biology, or a related field.
• Hands‑on experience with a range of in vitro radio biology techniques (e.g., clonogenic survival, DNA damage assays, cell cycle analysis).
• A solid understanding of the biological effects of ionizing radiation.
• Experience with targeted radiotherapeutics or preclinical imaging would be an advantage.
• Hands‑on experience with a range of in vivo techniques, such as nuclear imaging and biodistribution studies, is highly desirable.
• A collaborative mindset with strong…