Director, Clinical Science – Oncology Clinical Development

Company Overview

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success.

We’re uniting science, technology, and talent to get ahead of disease together.

Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most—advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.

The Director, Clinical Science – Oncology Clinical Development provides scientific leadership across defined components of study design, conduct, data review, and interpretation within an assigned clinical programme. Reporting to the Clinical Development Lead (CDL), this role operates within the asset‑level clinical strategy and contributes scientific depth and rigour to the execution of the Clinical Development Plan (CDP).

The Director, Clinical Scientist partners closely with the Senior Scientist and cross‑functional teams to support delivery of clinical studies, ensuring scientific quality, data integrity, and robust interpretation of clinical data. This role contributes to both study‑level activities and broader programme insights, without holding accountability for asset‑level strategy or overall study delivery.

This is a scientific individual contributor role requiring deep oncology clinical development expertise, strong analytical and collaboration skills, and the ability to operate effectively within a complex, matrixed environment.

• Provide scientific leadership across defined components of study‑level activities, including protocol development, study design, data review, and interpretation, within the strategic direction set by the CDL
• Serve as a core member of the Clinical Matrix Team (CMT), ensuring scientific alignment across study objectives, timelines, and deliverables
• Provide scientific insight to the CDL and Senior Scientist to inform asset‑level strategy, benefit–risk assessment, and programme‑level decision‑making
• Ensure the scientific quality and consistency of key clinical and regulatory documents, including protocols, Investigator’s Brochures, Clinical Study Reports, and submission materials
• Apply scientific and clinical expertise to analyse and interpret data, ensuring rigour, integrity, and relevance to the target patient population
• Engage with internal and external stakeholders, including investigators and Key External Experts, to support study execution and scientific exchange
• Contribute to a culture of scientific excellence, innovation, and continuous improvement within Oncology Clinical Development

• Provide scientific input into protocol development and study design, ensuring robustness, feasibility, and alignment with CDP‑defined objectives and regulatory requirements
• Author or co‑author key study documents (e.g., Clinical Study Proposals), contributing to preparation and presentation at governance forums such as Protocol Review Boards
• Support study conduct by addressing scientific questions, ensuring data integrity, and maintaining alignment with protocol and regulatory standards
• Provide scientific input into study‑level decisions related to protocol implementation and study conduct, within the strategic framework defined by the CDL
• Present and support the scientific rationale and study design at Investigator Meetings and respond to scientific inquiries from study sites
• Support implementation of…