Postdoctoral Research Fellow

Postdoctoral Fellow (Papayannopoulos Lab)

Contract term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment.

Salary for this Role: From £47,500 with benefits, subject to skills and experience

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher.

This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

The Papayannopoulos Lab investigates how the innate immune system responds to infection while limiting harmful inflammation. Focusing on fungal and bacterial infections, we study how immune cells such as neutrophils and macrophages coordinate antimicrobial responses, prevent sepsis and regulate inflammatory diseases.

Using cutting-edge immunology, cell biology and in vivo disease models, our research aims to uncover new mechanisms that could lead to improved treatments for infections and inflammatory diseases.

We are seeking an ambitious Postdoctoral Research Fellow to lead an independent research project investigating how the recognition and processing of PAMPs and DAMPs regulates inflammation and microbial control during fungal and bacterial infections.

Working within a collaborative and multidisciplinary research environment, you will design and deliver innovative research using molecular, cellular and in vivo approaches, while contributing to high-impact publications, grant applications and the wider research programme. This ERC-funded position offers an excellent opportunity to establish your independent research profile within a world-leading biomedical research institute.

• Leading an independent research project focused on innate immune responses during infection.
• Designing and carrying out experiments using in vitro systems and mouse models of disease.
• Applying molecular, cellular and biochemical techniques including flow cytometry, CRISPR, microscopy and transcriptomic analysis.
• Analysing experimental data and publishing findings in leading scientific journals.
• Presenting research at national and international conferences.
• Contributing to grant applications and collaborative research initiatives.
• Mentoring PhD students and collaborating with researchers across the Crick and external partners.

You will have:

• PhD in immunology, infection biology, biochemistry, cell biology or a related discipline, or be in the final stages of PhD submission.*
• Strong knowledge of immunology, biochemistry and cell biology.*
• Experience working with molecular, cellular and mouse models of disease.*
• Evidence of first-author publications or manuscripts submitted for publication.*
• Excellent experimental design, scientific writing, organisational and collaborative working skills.*
• A passion for innovative research and strong drive to publish high-quality science.*
• Experience in myeloid cell biology or cellular signalling pathways.
• Experience with advanced biochemical or cellular biology techniques.

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture!

• We are
  bold
  . We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do things differently.
• We are
  open
  . We’re highly collaborative and interactive,…