Senior Laboratory Research Scientist - Tumour and Host Metabolism Laboratory

Salary for this Role:

From £47,080 with benefits, subject to skills and experience.

Senior Laboratory Research Scientist
- Tumour and Host Metabolism Laboratory

Karen Vousden

28/Aug/ GMT

Senior Laboratory Research Scientist
- Tumour and Host Metabolism Laboratory

Reporting to:
Karen Vousden
- Principal Group Leader

This is a full-time, 2 year fixed term position on Crick terms and conditions of employment

From £47,080 with benefits, subject to skills and experience

28th of August 2026 m

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world‑class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state‑of‑the‑art infrastructure, cutting‑edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher.

This gives us the freedom to take risks and carry out high‑quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

We are looking for a Senior Laboratory Research Scientist position to join the Vousden Lab
- Tumour and Host Metabolism Laboratory for two years.

We focus on how changes in metabolism affect cancer development and progression. We also investigate how cancer affects the whole body, including the influence of primary tumours on distant organs and the interplay between cancers and systemic conditions such as obesity, cachexia and aging.

You will support several projects aimed at understanding the role of metabolism in controlling various aspects of cancer cell behaviour, such as the regulation of reactive oxygen species (ROS), epithelial to mesenchymal transition and cancer/host cell interactions.

This post will be an exciting opportunity to be part of a research group that is focused on investigating how metabolism affects tumour development using various in vitro and in vivo techniques. Projects in the laboratory are highly interdisciplinary and the successful candidate will be exposed to a broad range of cutting‑edge in vitro and in vivo approaches in cancer research, becoming an integral member of the team.

• Design and implementation of experiments to assess nutrient and metabolic requirements of cancer cells
• Maintain cancer cells in culture and assess growth rates and survival
• Perform western blot analysis of protein expression
• Reagent preparation, sample accession and preparation
• Collaboration and interaction with other group members, as required
• General contribution to the smooth running of the lab, including contribution to general lab tasks
• Presentation and discussion of results at lab meetings

You will have:

• PhD (or equivalent experience) in the area of molecular biology, cancer models and metabolism*
• Understanding of oxidative stress and ROS*
• Technical metabolomic or proteomic analysis*
• At least 3 years postdoctoral experience (or equivalent experience)*
• Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals
• Evidence of data presentation at scientific meetings
• Experience of experimental design*
• Ability to work independently and also capable of interacting within a group
• Metabolic pathway analysis (desirable)

Minimum criteria*

Everyone who works at the Crick has a valuable role to play in advancing the Crick’s mission and shaping our culture.

• We are bold
  . We make space for creative, dynamic and imaginative ideas and approaches. We’re not afraid to do…