Research Scientist, Radiobiology

Your mission is to apply your skills in radio biology to support the preclinical development of our innovative Bicycle Radio-Conjugates (BRCs). You will conduct key in vitro and in vivo experiments generating the high-quality data needed to understand the efficacy and mechanism of action of our next-generation cancer therapies.

Working location: This is a hybrid position with the majority of attendance being at our office in London (up to 4 days per week) in the vicinity of Kings Cross with an ongoing requirement to visit the Cambridge Office up to 2 days per month.

YOUR RESPONSIBILITIES

Scientific & Project Execution

• Conduct in vitro and in vivo studies to evaluate the efficacy mechanism of action and radiobiological effects of our BRCs following established study designs.
• Perform a range of assays to probe DNA damage response cell cycle effects and mechanisms of cell death.
• Characterize the effects of targeted radionuclide therapy on both tumour cells and the tumour microenvironment.
• Support radio biology research conducted through CROs and academic collaborations by assisting with material transfer and data organization.

Data Analysis & Communication

• Diligently document all experimental work and clearly communicate results to your manager and project team.
• Contribute to the identification of potential pharmacodynamic biomarkers through careful experimental work.
• Contribute to scientific publications and conference presentations through your data generation and analysis.

WHO ARE YOU: SKILLS & COMPETENCIES

Knowledge & Expertise

• Core Expertise: You apply solid scientific knowledge to plan and conduct radio biology experiments with growing independence.
• Data / Insight: You interpret experimental results identifying trends and drawing clear conclusions from your data.
• Knowledge Sharing: You share your expertise and observations with peers to build the teams collective capability.

Job Complexity

• Task / Project Delivery: You deliver work of moderate complexity independently taking ownership of your assigned experiments and ensuring reliable results.
• Problem-Solving: You adapt established methods to address new scientific challenges and troubleshoot issues in your experiments.
• Strategic Impact: You contribute key insights and reliable data that support team decision-making on a project level.

Independence

• Autonomy: You work independently on defined projects with limited oversight on routine work.
• Decision-Making: You select appropriate methods to achieve experimental objectives and deliver high-quality data.
• Leadership / Mentorship: You provide guidance to less experienced colleagues sharing your knowledge of specific assays and techniques.

Values & Behaviours

One Team

• Collaboration: You work constructively within and across teams to ensure your work is aligned with project goals.
• Inclusive Leadership:
  You encourage input from colleagues with different perspectives to enhance the quality of your work.
• Mentorship / Support: You actively share knowledge and offer support to your peers.

Adventurous

• Innovation: You suggest new approaches to experiments or improvements to existing assays.
• Risk-Taking: You learn from experimenting with novel methods and are willing to try new techniques.
• Change Leadership: You support the teams transition to new processes or technologies.

Dedicated to our Mission

• Accountability: You take ownership for the quality and reliability of your experimental results.
• Resilience: You remain focused and determined when experiments do not go as planned.
• Inspiration: You demonstrate commitment by linking your daily work to our mission of helping patients.

Qualifications :

• A strong educational background in radio biology cancer biology or a related field.
• Hands-on experience with a range of in vitro radio biology techniques (e.g. clonogenic survival DNA damage assays cell cycle analysis).
• A solid understanding of the biological effects of ionizing radiation.
• Experience with targeted radiotherapeutics or preclinical imaging would be an advantage.
• Hands-on experience with a range of in vivo techniques such as nuclear imaging and biodistribution studies is highly desirable
• A collaborative mindset with strong organizational and…