Postdoctoral Training Scientist Job London area,Greater London England UK,Research/Development

MRC Postdoctoral Research Scientist in Gene Regulation and High-Throughput CRISPR screens Genomic Variation and Disease Group (LMS 2880)

Salary: £42,694 plus London allowance £5,560 per annum*

Additional allowances comprises at £1,000 lump sum settlement allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.

3 years fixed term | Full-time |

Location:

Hammersmith London

Closing Date: 4 October 2026

Overall purpose:

The Genomic Variation and Disease Group works at the intersection of medical genetics, bioinformatics, and molecular biology to explore the mechanisms underlying human diseases. The group uses CRISPR/Cas9 genome editing and synthetic genomics for mouse or human genome rewriting to model disease-causing chromosomal structural variants (SVs) and study their functional consequences. Our challenge is understanding how this type of genomic variation affects molecular and cellular processes to influence organismal phenotypes.

Key

skills:

Background in the field of gene regulation and/or developmental genetics
Experience in mouse ES cell culture and common techniques in molecular biology
Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens
Experience in the preparation of targeted NGS libraries is an advantage
Experience in in vitro neuronal differentiation is an advantage
Experience in immunofluorescence and microscopy imaging is an advantage
Experience in single-cell technologies is an advantage
Experience in high-throughput chromosome conformation capture (cHi-C) is an advantage
Experience in ATAC-seq and Cut&Tag/ChIP-seq is an advantage

Main Responsibilities:

The general responsibilities will include, but are not limited to, the following activities:

Work with group members and collaborators as well as independently on experimental design, data analysis, visualization, and interpretation
To prepare work for publication and grant submissions
To present at seminars and conferences as necessary
To contribute to the smooth running of the Group’s/Unit’s laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories
To assist in the supervision of undergraduate and postgraduate research students and research assistants as required

Education / Qualifications / Training required (will be assessed from application form):

Essential:

PhD (or equivalent) in Molecular Genetics or a closely related discipline

Knowledge and experience (will be assessed from application form and at interview):

Essential:

Background in the field of gene regulation and/or developmental genetics
Experience in mouse ES cell culture and common techniques in molecular biology
Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens
Excellent written communication skills in English and the ability to write clearly for publication

Desirable:

Experience in the preparation of targeted NGS libraries
Experience in in vitro neuronal differentiation
Experience in immunofluorescence and microscopy imaging
Experience in single-cell technologies
Experience in high-throughput chromosome conformation capture (cHi-C)
Experience in ATAC-seq and Cut&Tag/ChIP-seq is an advantage

Personal skills / Behaviours / Qualities (will be assessed at the interview):

Essential:

Ability to conduct reproducible research
Ability to conduct a detailed review of recent literature
Ability to develop and apply new concepts
Creative approach to problem-solving
A keen interest in learning new skills
Excellent verbal communication skills in English and the ability to deal with a wide range of people
Ability to motivate others to produce a high standard of work
Ability to organise own work with minimal supervision
Ability to prioritise own work in response to deadlines
Advanced computer skills, including word-processing, spreadsheets and the internet
Willingness to work as part of a team and to be open-minded and cooperative
Flexible attitude towards work
Discipline and regard for confidentiality and security at all times
Willingness to undertake any necessary training for the role

Additional information:

Please note that applications may be reviewed by both LMS and Imperial staff