Senior Research Investigator; Biologics Pharmacology

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

We're seeking a Senior Research Investigator specialising in biologics drug development to contribute to the pharmacology and translational biology strategy of our novel large molecule therapeutics, harnessing the transformative power of our cutting-edge AI drug design engine.

Within the Biologics Design and Research team, you will play a pivotal role in our drug discovery projects, working with key internal and external stakeholders to drive the pharmacology strategy of complex projects in early discovery through to candidate selection and, ultimately, advancing candidates towards the clinic.

• Translational Biology Strategy: Design, execute, and oversee comprehensive pharmacology plans for our large molecule therapeutics.
• In Vivo & In Vitro Evaluation: Lead the design and execution of in vivo efficacy and complex in vitro functional assays to ensure high-quality data generation.
• Drive Project Milestones: Act as the Biology Lead for assigned projects, coordinating complex internal workflows and external CROs to efficiently progress candidates toward critical go/no-go decisions and program milestones.
• New Target Identification: Collaborate with computational biology and design teams to identify, evaluate, and bring new biologics projects into the portfolio, assessing biological feasibility and therapeutic potential.
• Collaborative Platform Building: Partner closely with interdisciplinary teams (ML, Biology, Comp Bio) to help build our generative AI platform, ensuring the pharmacology data you generate is effectively fed back into design loops.

• PhD in Immunology, Cancer Biology, Molecular Biology, Biochemistry, Pharmacology or a related scientific discipline.
• 5+ years' professional experience in an industry role within a biotech or pharma setting.
• Strong scientific expertise in disease models and their use in biologics drug development.
• Significant experience in the design and execution of studies to support project progression in biologics drug discovery and development.
• Experience with in the immunology, inflammation or oncology therapeutic areas.
• Proficiency with modalities such as multi-specifics or antibody drug conjugates (ADCs).
• Demonstrated proficiency in fostering and managing external collaborations with Contract Research Organizations (CROs) and academic groups.
• Genuine passion for applying AI/ML to drug design.
• Excellent communication (written and verbal) and interpersonal skills, with a proven ability to work effectively in a cross-functional, collaborative team environment.

• Experience leveraging machine learning or computational biology techniques for biologics design and optimisation.
• Experience in antibody discovery, engineering, and optimisation strategies.
• In-depth understanding of protein structure-function relationships of antibodies.

This is a hybrid role requiring attendance in the London office 3 days a week (currently Tuesday, Wednesday, and one other day depending on team).

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law.