Postdoctoral Research Associate in Proteomics; LC-MS​/MS

Los Alamos National Laboratory (LANL) Bioscience Division, Biochemistry and Biotechnology Group (B-TEK) is seeking a proteomics-focused Postdoctoral Research Associate to design, execute, and improve large-scale proteomics pipelines. This role emphasizes high-throughput LC-MS/MS proteomics from sample preparation through quantitative/qualitative analysis and bioinformatics, with a strong focus on rigorous quality control to ensure defensible results across mission-relevant studies. You will work in a highly collaborative environment with access to multiple high-resolution Orbitrap platforms and high-performance computing resources.

The position includes opportunities to publish in high-impact journals and present at conferences.

• Design and execute LC-MS/MS proteomics experiments (DIA and/or DDA) including sample preparation, acquisition, and downstream analysis.
• Develop and/or refine quantitative proteomics workflows with and without isobaric labeling, as appropriate to the study design.
• Implement, track, and document QC standards (reference, quantitative, process control, and system-performance controls) across studies.
• Integrate proteomics results with biological context and complementary measurements; contribute to multi-omics efforts when relevant.
• Utilize existing bioinformatics tools and develop project-specific computational workflows.
• Improve computational pipelines for feature detection, annotation, normalization, visualization, and reproducible reporting.
• Communicate results through peer-reviewed publications, technical reports, and conference presentations.

• Ph.D. in a STEM field (e.g. analytical chemistry, biochemistry, bioinformatics, computational biology, data science) completed within the last five years (or expected by the start date).
• Strong peer-reviewed publication record commensurate with career stage.
• Demonstrated excellence in written and oral communication (e.g., manuscripts, reports, presentations).
• Experience processing DIA proteomics data and/or developing computational workflows for proteomics or metabolomics datasets.
• Experience working with high-dimensional and complex datasets.
• Deep understanding of mass spectrometry fundamentals, proteomics, and
  -omics pipeline concepts.
• Hands‑on experience spanning sample preparation, instrument operation/data acquisition, and data analysis.
• Proficiency in scientific programming or data analysis using Python, R, MATLAB, or a comparable language.
• Working knowledge of statistical analysis, data visualization, and reproducible computational practices.
• Ability to obtain a DOE Q clearance (typically requires U.S. citizenship).

• Demonstrated experience with large-scale proteomics studies and quantitative LC-MS/MS data analysis.
• Experience with DDA/DIA, spectral library approaches, and/or advanced analysis modalities (e.g., de novo or top‑down) is a plus.
• Familiarity applying machine learning and statistics to develop robust biomarker panels.
• Demonstrated experience using bioinformatics tools and developing computational workflows.
• Strong background in multivariate statistical analysis and predictive modeling.
• Experience establishing QC methods addressing background, extraction efficiency, precision, LC reproducibility, and standards/sample pools.
• Familiarity with common proteomics software ecosystems (e.g., Proteome Discoverer, Perseus, Max Quant, or similar).
• Experience with automation/robotics for sample preparation is a plus.

The work location for this position is onsite and located in Los Alamos, NM. All work locations are at the discretion of management.

• Current resume/CV
• Current official transcripts
• Cover letter/personal statement of interest, not to exceed one page

Due to federal restrictions contained in the current National Defense Authorization Act, citizens of the People's Republic of China-including the special administrative regions of Hong Kong and Macau-as well as citizens of the Islamic Republic of Iran, the Democratic People's Republic of Korea (North Korea), and the Russian Federation, who are not Lawful Permanent Residents ( green card  holders) are prohibited from accessing facilities that support the mission, functions, and operations of national security laboratories and nuclear weapons production facilities, which includes Los Alamos National Laboratory.

Located in beautiful northern New Mexico, Los Alamos National…