Senior Scientist, DMPK

Senior Scientist, DMPK

Annual Base Salary: DOE, $140,000-$185,000 along with bonus eligibility and a comprehensive benefits package

Location: Los Angeles, CA

The Ellison Medical Institute, formerly known as the Ellison Institute of Technology Los Angeles, strives to spark innovation, leverage technology, and drive interdisciplinary, patient-centered research to continually enhance health, reimagine and redefine cancer care, and transform lives. Established in 2016 as a medical research and development center, the Institute features innovation labs for artificial intelligence and molecular analytics and was among the first organizations to vertically integrate the interdisciplinary study and treatment of disease.

We offer multifaceted programs, including a preventative medicine and cancer clinic, cross-disciplinary research laboratories, a health policy think-tank, and community outreach and educational programs.

Please visit emila.org for more details.

The Ellison Medical Institute is seeking an accomplished and passionate Senior Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to join our Translational Biology team. In this high-impact role, you will apply your expertise in pharmacokinetics (PK), toxicology (TOX), and drug metabolism (ADME) to accelerate the advancement of groundbreaking new molecular entities as our lead compound advances into IND-enabling and first-in-human studies.

This is a pivotal role in shaping the nonclinical strategy, managing CRO partnerships, and authoring the IND nonclinical modules to support regulatory filings and clinical transition. The ideal candidate thrives in a dynamic start-up environment and can balance hands‑on scientific work with strategic oversight.

This is a unique opportunity to be at the forefront of early‑stage drug development, in a collaborative, multidisciplinary environment, where your contributions will help shape the future of medicine.

• Drive Innovation: Contribute to the advancement of cutting‑edge drug development and therapeutic strategies that transform patient care.
• Be at the Forefront: Work with a world‑class team and integrate new technologies in PK/TOX and ADME studies to accelerate the drug discovery pipeline.
• Make an Impact: Help shape clinical trial strategies and regulatory pathways that will support the successful progression of therapeutic candidates into clinical trials.

• Lead PK/TOX and ADME Studies
  • Design, execute, and interpret ADME, PK, and toxicology studies (in vitro and in vivo) to characterize compound properties and support IND submission.
  • Develop study designs aligned with FDA/EMA guidance for IND‑enabling packages, including dose range finding and GLP toxicology studies.
  • Integrate PK/TOX findings into overall development strategy and advise on risk assessment for first‑in‑human studies.
• Data Analysis and Modeling
  • Perform or direct PK and ADME data analysis using Phoenix Win Nonlin or equivalent modeling software.
  • Conduct human PK predictions and first‑in‑human dose projections to inform clinical study design.
  • Synthesize and communicate results in cross‑functional meetings to guide decision‑making and clinical translation.
• CRO Management and Oversight
  • Identify, qualify, and manage CROs for ADME, PK, and toxicology studies, ensuring high‑quality data delivery and adherence to GLP standards.
  • Provide clear technical direction, review study protocols, monitor study progress, and critically assess data deliverables.
  • Establish timelines, budgets, and deliverables for external studies and ensure alignment with regulatory milestones.
• Regulatory and IND Authoring
  • Lead the preparation and authorship of nonclinical sections (Module 2.6, 2.7.1, and 4.2) of the IND, collaborating with internal teams and external consultants as needed.
  • Support responses to regulatory agency questions and contribute to the nonclinical components of investigator brochures and clinical protocols.
  • Ensure that all documentation and data are audit‑ready and compliant with ICH and FDA standards.
• Cross‑Functional Collaboration
  • Partner with clinical, CMC, and research teams to ensure preclinical findings…