Researcher, Research​/Development, Research Scientist

Department: Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine

Location: Health Sciences Center

Time Type: Full time

Worker Type: Regular

Job Req : R108087

Minimum Requirements: Master’s degree in a related field and two (2) years of relevant experience or the equivalent combination of education and experience. Grade 6 (Salaried)

The Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, is seeking a Researcher supported by NIH grants. The selected candidate will study the molecular mechanisms underlying diabetes‑induced cardiovascular complications. The laboratory uses a combination of state‑of‑the‑art approaches which are integrated with primary cardiovascular cell cultures, cardiovascular organoids and transgenic techniques, as well as in vivo conditional inducible knockout and knock‑in animal models to elucidate the molecular mechanisms underlying diabetes‑induced metabolic disorder and cardiovascular complications.

The Researcher will prepare and conduct experiments, data analysis, interpretation and will write reports and manuscripts, as well as make presentations.

This is a grant funded position with continued employment contingent on grant renewals. We are unable to sponsor or take over sponsorship of a work visa for this position.

• Conduct and organize all biochemical, physiological, morphological, and histochemical studies. Perform data collection and analysis and perform research and related tasks on specified projects. Write reports and manuscripts, as well as make presentations.
• Develop new techniques; organize and conduct statistical analysis of data generated from study results.
• Update research projections: and conduct research on past literature, monitor current research literature for relevant information. This includes peer‑reviewed manuscripts of research abstracts at national and international meetings.
• Collect, edit, and present research outcomes. May recommend new ideas for ongoing lines of research and may interpret and advise faculty regarding extramural funding source guidelines and requirements.

• Self‑motivated, productive PhD, MD or DVM.
• Strong background in molecular biology, cell biology, pathophysiology, cardiology, and pharmacology.
• Previous experience in working with metabolic syndrome‑associated complication and chemotherapy‑induced cardiotoxicity animal models and human organoid models including diabetic cardiomyopathy, atherosclerosis, diabetic nephropathy, and doxorubicin‑induced cardiotoxicity.
• Previous experience in small animal ultrasound imaging (echocardiography), flow cytometry, primary cell culture, human iPSC, human organoids, lipid metabolism, radioactive isotope, transcriptome, single cell/nuclear and spatial RNA sequencing, and virus handling.

• Tissue culture of primary adipocytes, cardiomyocytes, tubule cells, and/or hepatocytes.
• Human iPSC culture and human organoids development
• Transgenic mice handling.
• Metabolic syndrome model induction and monitoring.
• Heart, blood vessel, kidney, and liver function evaluation.
• Histopathology of blood vessel, heart, kidney, and liver and specialized imaging software.
• Scientific report and proposal writing.

Target Compensation Minimum: $52,993.00
Target Compensation Maximum: $79,540.00
Compensation will be commensurate to candidate experience.

The University of Louisville is an Equal Employment Opportunity employer. The University strives to provide equal employment opportunity on the basis of merit and without unlawful discrimination on the basis of race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity or expression, veteran status, marital status, or pregnancy. In accordance with the Rehabilitation Act of 1973 and the Vietnam Era Veteran Readjustment Act of 1974, the University prohibits job discrimination of individuals with disabilities, Vietnam era veterans, qualified special disabled veterans, recently separated…