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Director Enterprise Architecture

Job in Macclesfield, Cheshire, SK11, England, UK
Listing for: ASTRAZENECA UK LIMITED
Full Time position
Listed on 2026-02-16
Job specializations:
  • IT/Tech
    Systems Engineer, Cloud Computing, IT Project Manager
Salary/Wage Range or Industry Benchmark: 150000 - 200000 GBP Yearly GBP 150000.00 200000.00 YEAR
Job Description & How to Apply Below

Are you ready to develop an enterprise architecture that strengthens product quality and speeds up the provision of medications to patients worldwide? In this role, you will lead the end-to-end architecture across Pharmaceutical Technology, Quality Control, and Global Quality Assurance-linking datasets, artificial intelligence and machine learning solutions, applications, and platforms to clear business outcomes in a highly regulated environment. From day one, you will develop a vision for architecture spanning one to five years and bring coherence to a sophisticated global portfolio.

Can you see yourself simplifying and standardizing how we assure product quality across sites, minimizing exposure and expenses while growing agility? You will create the foundations that enable faster, safer decisions from lab to plant to release. You will join an experienced architecture community that moves quickly, challenges how work gets done, and unites teams with varied strengths behind pragmatic standards.

Your judgment will guide strategic choices, your governance will unlock value at pace, and your leadership will build the capabilities that keep our technology ecosystem resilient and ready for what's next.

  • Proven experience providing enterprise design leadership across Business, Data, AI/ML, Application, and Technology within Pharmaceutical Technology, QC, and Global QA.
  • Demonstrated ability to define architecture strategy, standards, and 1-5 year roadmaps aligned to business priorities and supervised operating requirements.
  • Authority to make and govern strategic architecture decisions; experience signing off solution blueprints and guiding segment architectures.
  • Track record of continuously aligning capabilities with business objectives, rationalizing and simplifying portfolios to reduce risk and cost.
  • Active participation in cross-functional decision-making bodies (e.g., project steering teams, technical design authorities) and design/standards governance forums.
  • Evidence of championing enterprise architecture initiatives across technology organizations; ability to analyse market and industry trends and assess impact.
  • Leadership of EA standards, processes, and tooling, with embedded GxP validation and measures ensuring data reliability in architectures.
  • Experience establishing partnerships with key technology suppliers and system integrators; evaluating products and shaping business cases.
  • Dedication to capability development through mentoring, collaborative learning groups, and standards ownership.
  • People leadership of 5-8 architects with varied seniority, plus matrix leadership across adjacent domains and programs; accountable for coaching, performance management, capability building, and delegation.
  • Success operating with a global remit across multiple countries and functions, with interfaces to R&D, Manufacturing/Tech Ops, and Supply Chain.
Desirable Skills/Experience
  • Certification or formal training in enterprise architecture frameworks (e.g., TOGAF) and experience with modern EA tooling (e.g., LeanIX, Ardoq).
  • Deep familiarity with GxP, 21 CFR Part 11, Annex 11, and data integrity principles, including experience navigating audits and validations.
  • Hands‑on leadership of cloud‑centric architectures (Azure/AWS), data platforms, and AI/ML enablement in QC/QA contexts.
  • Knowledge of quality and manufacturing ecosystems such as QMS, LIMS, MES, serialization, and release/lot disposition processes.
  • Proven outcomes in portfolio simplification, cost reduction, and risk mitigation at enterprise scale.
  • Strong vendor management and negotiation skills; ability to structure value‑focused contracts and partnerships.
  • Executive communication and storytelling skills that influence senior stakeholders and align diverse teams.
  • Advanced degree in a relevant field or equivalent experience driving transformation in complex, regulated environments.
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