Associate Director; Analytical Team Leader Early Chemical Development, Pharmaceutical Science

Macclesfield UK - 4 days on site per week

AstraZeneca is a global, science‑led, patient‑focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. We pioneer new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

Pharmaceutical Sciences is a function within the AstraZeneca Biopharmaceuticals R&D unit that builds innovative, efficient solutions, transforming molecules into investigational medicines that meet unmet patient needs. Our portfolio includes traditional small molecules, nucleotide‑based therapies and nano‑medicines across various therapy areas.

ECD is a world‑class CMC department responsible for early‑phase Drug Substance. The department’s scope ranges from early engagement with Discovery Chemistry to the manufacture of Phase II clinical material. Key skill areas include Analytical Chemistry, Crystallisation, Isotope Chemistry, Large‑Scale Laboratory (Kilo‑Lab) Manufacturing, Process Chemistry, Process Design, Process Engineering, Route Design and Separation Science.

We are looking for an Analytical team leader to join ECD’s Analytical Section. Candidates should have extensive experience in analytical science and a passion for leading and developing team members.

• Accountable for the planning and execution of analytical deliverables in support of internal GMP manufacturing and stability.
• Contribute to the development of departmental goals and link them to team members’ individual goals.
• Ensure work is performed in accordance with Safety, Health & Environment (SHE), quality and compliance standards, including GMP, and deliver improvement and action plans as required.
• Lead continuous improvement initiatives to drive organisational effectiveness and productivity through the introduction of new digital tools.

• Degree or equivalent scientific qualification (Masters or PhD preferred) in a relevant field such as Chemistry, Analytical Chemistry, Pharmaceutical Sciences, or a closely related subject area, with substantial experience in analytical science within the pharmaceutical industry, preferably in CMC or drug substance development.
• Solid understanding of the regulatory environment for clinical development and strong working knowledge of the pharmaceutical industry to ensure industry standards are applied.
• Extensive experience in analytical science, preferably with specific experience driving performance through organisational effectiveness.
• Demonstrated leadership within a scientific environment, with a strong background in leading, coaching, and developing analytical scientists to deliver high performance and build team capability.
• Experience working across cross‑functional drug development teams, collaborating effectively with disciplines such as process chemistry, manufacturing, engineering, and other CMC skill groups to support the progression of early‑phase drug substance activities.
• Strong communication and stakeholder management skills, with the ability to work closely with manufacturing partners, project teams, and specialist scientific groups to ensure alignment on priorities, delivery, and quality expectations.
• A strong understanding and practical experience of the principles and management of SHE and cGMP.

• Experience working within a CMC development organisation.
• Experience with digital planning tools and application of Lean principles.
• An appreciation of GMP manufacturing and ICH Q7 principles in the clinical phase.

When we put unexpected teams in the same room, we unleash bold thinking and inspire life‑changing medicines. In‑person working provides the platform to connect, work at pace and challenge perceptions. We expect a minimum of four days per week in the office, while respecting individual flexibility.

The successful candidate will receive a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, a performance recognition scheme and a competitive, generous remuneration package.

Our mission is to build an inclusive and equitable environment. We want people to feel they belong  welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments and accommodations to help all candidates perform at their best.